Methylphenidate does not improve interference control during a working memory task in young patients with attention-deficit hyperactivity disorder

Prehn-Kristensen, Alexander; Krauel, Kerstin; Hinrichs, Hermann; Fischer, Jochen; Malecki, Ulrike; Schuetze, Hartmut; Wolff, Stephan; Jansen, Olav; Duezel, Emrah; Baving, Lioba

doi:10.1016/j.brainres.2011.02.075

Cited by 31 publications

(29 citation statements)

References 66 publications

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“…We found less stopping-related activation in 10 ADHD adult participants currently taking psychostimulants as compared to 25 ADHD participants not currently taking psychostimulants. This is in contrast to the majority of studies, which report an increase in neural activation following psychostimulant administration in ADHD youth (Vaidya et al, 1998; Shafritz et al, 2004; Epstein et al, 2007; Prehn-Kristensen et al, 2011; Rubia et al, 2011a; Rubia et al, 2011b). Long-term medication use is thought to normalize an underactive stopping-related response in ADHD youth (Rubia et al, 2013; Schweren et al, 2013) and this has been demonstrated in other domains, including attention-related (Hart et al, 2013) and timing-related (Hart et al, 2012) neural activation.…”

Section: Discussioncontrasting

confidence: 97%

Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: Preliminary findings on the effects of medication and symptom severity

Congdon

Altshuler

Mumford

et al. 2014

Psychiatry Research: Neuroimaging

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Studies of adults with attention-deficit/hyperactivity disorder (ADHD) have suggested that they have deficient response inhibition, but findings concerning the neural correlates of inhibition in this patient population are inconsistent. We used the Stop-Signal task and functional magnetic resonance imaging (fMRI) to compare neural activation associated with response inhibition between adults with ADHD (N = 35) and healthy comparison subjects (N = 62), and in follow-up tests to examine the effect of current medication use and symptom severity. There were no differences in Stop-Signal task performance or neural activation between ADHD and control participants. Among the ADHD participants, however, significant differences were associated with current medication, with individuals taking psychostimulants (N = 25) showing less stopping-related activation than those not currently receiving psychostimulant medication (N = 10). Follow-up analyses suggested that this difference in activation was independent of symptom severity. These results provide evidence that deficits in inhibition-related neural activation persist in a subset of adult ADHD individuals, namely those individuals currently taking psychostimulants. These findings help to explain some of the disparities in the literature, and advance our understanding of why deficits in response inhibition are more variable in adult, as compared with child and adolescent, ADHD patients.

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Section: Discussioncontrasting

confidence: 97%

Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: Preliminary findings on the effects of medication and symptom severity

Congdon

Altshuler

Mumford

et al. 2014

Psychiatry Research: Neuroimaging

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show abstract

“…These data are consistent with other studies showing first, that adults (Johnson et al, 2001;King et al, 2007;Murphy et al, 2001;Rapport et al, 2001) as well as children with ADHD (Bedard et al, 2002;Prehn-Kristensen et al, 2011), are impaired on the Stroop interference measure compared to control populations. Second, Biederman et al, (2008b) showed that medication did not normalize Stroop interference control in young adults with ADHD.…”

Section: Neuropsychological Assessment Of Adhd-diagnosed College Studsupporting

confidence: 92%

Do Stimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) Enhance Cognition?

Advokat¹,

Vinci²

2012

Current Directions in ADHD and Its Treatment

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“…Some evidence of impaired interference control in the context of WM has been reported in samples of children and adolescents with ADHD (Cornoldi et al, 2001;Palladino and Ferrari, 2013;Prehn-Kristensen et al, 2011). Interestingly, Prehn-Kristensen et al (2011) found that interference control, linked to fMRI activity in the caudate, was not adequately enhanced by Methylphenidate in children and adolescents with ADHD. Few studies have targeted interference control during WM updating in adult ADHD samples and results are heterogeneous.…”

Section: Discussionmentioning

confidence: 92%

Deficient interference control during working memory updating in adults with ADHD: An event-related potential study

Stroux

Shushakova

Geburek-Höfer

et al. 2016

Clinical Neurophysiology

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Methylphenidate does not improve interference control during a working memory task in young patients with attention-deficit hyperactivity disorder

Cited by 31 publications

References 66 publications

Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: Preliminary findings on the effects of medication and symptom severity

Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: Preliminary findings on the effects of medication and symptom severity

Do Stimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) Enhance Cognition?

Deficient interference control during working memory updating in adults with ADHD: An event-related potential study

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