Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task

Lawrence, Carlie A.; Barry, Robert J.; Clarke, Adam R.; Johnstone, Stuart J.; McCarthy, Rory; Selikowitz, Mark; Broyd, Samantha J.

doi:10.1007/s00213-005-0144-y

Cited by 82 publications

(54 citation statements)

References 53 publications

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“…Children with AD/HDcom showed differences in P3 indicative of problems with cue orienting, and subsequent CNV differences indicating inefficient preparation for the upcoming stimulus, effects that were not present for an Oppositional Defiant Disorder (ODD) or co-morbid AD/HDcom and ODD group (Banaschewski et al, 2003). During a CPT, children with AD/HDcom were reported to show reduced frontal N1 and N2 amplitudes and parietal P2 and P3 amplitudes to target stimuli, indicating diminished evaluative and processing capabilities (Lawrence et al, 2005). Children aged 5-7 with AD/HD characteristics were reported to show an atypical Go-P3 effect suggesting deficient attentional resource allocation, and a difference in cue-P3 indicating impaired orienting (Spronk et al, 2008).…”

Section: Attentionmentioning

confidence: 98%

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Johnstone

Barry

Clarke

2013

Clinical Neurophysiology

Self Cite

148

132

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This article reviews the event-related potential (ERP) literature in relation to attention-deficit/hyperactivity disorder (AD/HD) over the years [2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012]. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are reviewed, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components. These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters. • Research focus and intensity has been in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions.• Some consistent differences from healthy controls are emerging, but more emphasis on replication and extension studies is needed to increase the consistency and specificity of results. AbstractThis article reviews the event-related potential (ERP) literature in relation to attentiondeficit/hyperactivity disorder (AD/HD) over the years 2002 to 2012. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are examined, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components.These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters.

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Section: Attentionmentioning

confidence: 98%

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Johnstone

Barry

Clarke

2013

Clinical Neurophysiology

Self Cite

148

132

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“…P300 has been used to track medication effects in children with AD/HD in other studies as well. For example, Lawrence et al (2005) recorded the P300 elicited by target stimuli in a visual CPT. A frontal shift in P300 observed in children with AD/HD was found to normalize following administration of methylphenidate.…”

Section: Attention-deficit/hyperactivity Disordermentioning

confidence: 99%

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan

Barry

Connolly

et al. 2009

Clinical Neurophysiology

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1,007

845

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“…Explicit analyses of Go-P3 evoked by the CPT in ADHD are rare, but some instances of diminished amplitude in patients have been observed [70,72,88,89].…”

Section: Psychophysiological Characteristicsmentioning

confidence: 99%

ADHD History of the Concept: the Case of the Continuous Performance Test

Albrecht

Sandersleben

Wiedmann

et al. 2015

Curr Dev Disord Rep

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The historic development of the attention deficit hyperactivity disorder (ADHD) construct is, in many cases, paralleled by research questions addressed with the continuous performance test (CPT). This task, the use of which dates back to the 1950s for the diagnosis of brain damage, requires responding to rare targets in a sequence of stimuli during prolonged assessment. In our review, we illustrate how the CPT was and still is used for the assessment of sustained attention and impulsivity as core features of ADHD. In addition to impaired performance at the neuropsychological level, the CPT also taps underlying brain activity that can be registered by neuroimaging techniques such as fMRI and EEG. The latter allows more detailed operationalization of ADHD theories, and reveals impairments at different stages of information processing. The CPT has also been applied for treatment evaluation. Recently, distinct genetic effects on preparation and response control or impulsivity were detected using the CPT. As such, the task remains a valuable tool for further investigations of genetic and environmental factors of ADHD.

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Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task

Cited by 82 publications

References 53 publications

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

ADHD History of the Concept: the Case of the Continuous Performance Test

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