Methylphenidate effects on height and bone age in ADHD children. 24 month follow up within the prospective ADDUCE project

Carucci, Sara; Romaniello, R.; Lampis, A.; Panei, Pietro; Coghill, D.; Zuddas, Alessandro

doi:10.1016/s0924-977x(16)31883-1

Cited by 2 publications

(1 citation statement)

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“…Twenty-six of the 29 eligible studies were self-controlled studies; among these 26 studies, 13 were retrospective studies that mostly utilized medical records [7,13,[15][16][17][18][19][20][21][22][23][24][25], whereas 12 monitored height outcomes in a prospective manner [26][27][28][29][30][31][32][33][34][35][36][37]. One study, which collected data using both medical records and prospective measurements, was categorized as a retrospective study [14]; the three remaining studies used a cross-sectional measurement method [38][39][40].…”

Section: Study Characteristicsmentioning

confidence: 99%

Effect of methylphenidate on height in pediatric attention-deficit hyperactivity disorder patients: a systematic review and meta-analysis

Duong,

Yang,

Yun

et al. 2023

Eur Child Adolesc Psychiatry

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Methylphenidate (MPH), a rst-line treatment for attention-de cit hyperactivity disorder (ADHD) management, has been the focus of debate for decades regarding its effect on growth. The aim of this PRISMA meta-analysis was to determine the effect of MPH on height in children/adolescents with ADHD, along with factors predictive of this effect. Available full-text articles were systematically reviewed to identify clinical studies of pediatric ADHD patients with height Z-score (HZS) data for monotherapy MPH-treated and non-treated groups. We estimated standardized mean differences (SMDs) of HZS or its changes from baseline (ΔHZS) between groups, then identi ed associated factors through subgroup analyses and meta-regression. For before-after treatment studies, the paired standard errors of ΔHZS were re-estimated to demonstrate in the forest plot. Risk of bias was analyzed using the Newcastle-Ottawa Scale. Among the 29 eligible studies, 26 before-after studies reported ΔHZS with self-control groups, whereas 11 compared ΔHZS or absolute HZS to other external (healthy/non-medicated) controls. A signi cant reduction was observed in the post-medicated group compared to the pre-medicated group, with high heterogeneity (SMD = -0.40; 95% con dence interval = [-0.54; -0.27]; I 2 = 91%). The study region, ADHD subtype, and stimulant-naïve status of patients at baseline may modify the effect on HZS. Because of the high clinical heterogeneity in observational studies, clinicians should consider the negative effect of MPH on height in ADHD patients by determining whether patients ful ll appropriate high-risk criteria. Further investigations are needed to identify the mechanism and the impact of reduction on the height reached in adulthood. Clinical Relevance And Implications Of The Meta-analysis1. There is a decrease in body height of children and adolescents with attention-de cit hyperactive disorder when using methylphenidate. Most evidences come from studies designed as observational, before-after treatment; the extent of this effect thus varies and depends on certain patient and study characteristics.2. Study region, ADHD subtypes, stimulant use history, and treatment dosage should be considered as minimum characteristics to be reported comprehensively in all studies measuring change of pediatric patients' height.3. Appropriate statistical methods should be applied to calculate exactly the outcomes in meta-analysis, especially for the before-after treatment design.

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Section: Study Characteristicsmentioning

confidence: 99%

Effect of methylphenidate on height in pediatric attention-deficit hyperactivity disorder patients: a systematic review and meta-analysis

Duong,

Yang,

Yun

et al. 2023

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

show abstract

Effect of methylphenidate on height in pediatric attention-deficit hyperactivity disorder patients: A Systematic Review and Meta-analysis

Duong

Yang

Yun

et al. 2023

Preprint

View full text Add to dashboard Cite

Methylphenidate (MPH), a first-line treatment for attention-deficit hyperactivity disorder (ADHD) management, has been the focus of debate for decades regarding its effect on growth. The aim of this PRISMA meta-analysis was to determine the effect of MPH on height in children/adolescents with ADHD, along with factors predictive of this effect. Available full-text articles were systematically reviewed to identify clinical studies of pediatric ADHD patients with height Z-score (HZS) data for monotherapy MPH-treated and non-treated groups. We estimated standardized mean differences (SMDs) of HZS or its changes from baseline (ΔHZS) between groups, then identified associated factors through subgroup analyses and meta-regression. For before-after treatment studies, the paired standard errors of ΔHZS were re-estimated to demonstrate in the forest plot. Risk of bias was analyzed using the Newcastle-Ottawa Scale. Among the 29 eligible studies, 26 before-after studies reported ΔHZS with self-control groups, whereas 11 compared ΔHZS or absolute HZS to other external (healthy/non-medicated) controls. A significant reduction was observed in the post-medicated group compared to the pre-medicated group, with high heterogeneity (SMD = -0.40; 95% confidence interval = [-0.54; -0.27]; I2 = 91%). The study region, ADHD subtype, and stimulant-naïve status of patients at baseline may modify the effect on HZS. Because of the high clinical heterogeneity in observational studies, clinicians should consider the negative effect of MPH on height in ADHD patients by determining whether patients fulfill appropriate high-risk criteria. Further investigations are needed to identify the mechanism and the impact of reduction on the height reached in adulthood.

show abstract

Methylphenidate effects on height and bone age in ADHD children. 24 month follow up within the prospective ADDUCE project

Cited by 2 publications

References 0 publications

Effect of methylphenidate on height in pediatric attention-deficit hyperactivity disorder patients: a systematic review and meta-analysis

Effect of methylphenidate on height in pediatric attention-deficit hyperactivity disorder patients: a systematic review and meta-analysis

Effect of methylphenidate on height in pediatric attention-deficit hyperactivity disorder patients: A Systematic Review and Meta-analysis

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