Methylphenidate effects on P300 responses from children and adolescents

Sanfins, Milaine Dominici; Hatzopoulos, Stavros; Torre, Osmar Henrique Della; Donadon, Caroline; Skarżyński, Henryk; Colella-Santos, Maria Francisca

doi:10.1016/j.ijporl.2017.01.034

Cited by 5 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, it has been shown that in healthy subjects taVNS generates an immediate modulatory effect with an increase in the amplitude of the P300 in auditory (Rufener et al, 2018) or visual (Ventura-Bort et al, 2018) tasks. This change is similar to those recorded during iVNS (Ventura-Bort et al, 2018;Sharon et al, 2021), neck VNS (Lewine et al, 2019) or pharmacological interventions aimed at stimulating the NE pathway (Sanfins et al, 2017). Other immediate effects have also been reported such as the reduction in the P300 latency and reduction in the reaction time response (Fischer et al, 2018;Rufener et al, 2018).…”

Section: Introductionsupporting

confidence: 82%

Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event related potential

Gurtubay

Perez-Rodriguez

Fernández³

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

IntroductionTranscutaneous auricular vagus nerve stimulation (taVNS) is a neuromodulatory technique that stimulates the auricular branch of the vagus nerve. The modulation of the locus coeruleus-norepinephrine (LC-NE) network is one of the potential working mechanisms of this method. Our aims were 1-to investigate if short and single applications of taVNS can modulate the P300 cognitive event-related potential (ERP) as an indirect marker that reflects NE brain activation under control of the LC, and 2-to evaluate the duration of these changes.Methods20 healthy volunteers executed an auditory oddball paradigm to obtain P300 and reaction time (RT) values. Then a 7 min active or sham taVNS period was initiated and simultaneously a new P300 paradigm was performed. We successively repeated the paradigm on 4 occasions with different time intervals up to 56 min after the stimulation onset.ResultsDuring active taVNS an immediate and significant effect of increasing the amplitude and reducing the latency of P300, as well as a shortening in the RT was observed. This effect was prolonged in time up to 28 min. The values then returned to pre-stimulation levels. Sham stimulation did not generate changes.DiscussionOur results, demonstrate differential facilitating effects in a concrete time window after taVNS. Literature about the modulatory effect of taVNS over P300 ERP shows a wide spread of results. There is not a standardized system for taVNS and currently the great heterogeneity of stimulation approaches concerning targets and parameters, make it difficult to obtain conclusions about this relationship. Our study was designed optimizing several stimulation settings, such as a customized earbud stimulator, enlarged stimulating surface, simultaneous stimulation over the cymba and cavum conchae, a Delayed Biphasic Pulse Burst and current controlled stimulation that adjusted the output voltage and guaranteed the administration of a preset electrical dose. Under our stimulation conditions, targeting vagal nerve fibers via taVNS modulates the P300 in healthy participants. The optimal settings of modulatory function of taVNS on P300, and their interdependency is insufficiently studied in the literature, but our data provides several easily optimizable parameters, that will produce more robust results in future.

show abstract

Section: Introductionsupporting

confidence: 82%

Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event related potential

Gurtubay

Perez-Rodriguez

Fernández³

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Even though most lesion studies point out a specific role of the frontal cortex in the generation of the novelty P3 (or P3a) (Knight, ; Li, Gratton, Yao, & Knight, ) there is also evidence for a critical involvement of the frontal cortex in the P3 (or P3b) generation (Basar‐Eroglu, Demiralp, Schürmann, & Başar, ; Wronka, Kaiser, & Coenen, ). This is further supported by the observation of reduced left DLPFC activation during selective attention tasks (Christakou et al., ; Miao et al., ; Sanfins et al., ) and decreased P3 amplitudes in frontal areas during an auditory oddball paradigm in patients with attention deficit hyperactivity disorder (ADHD) (Janssen, Geladé, van Mourik, Maras, & Oosterlaan, ; Johnstone, Barry, & Clarke, ). Of note, pharmacological interventions in ADHD that typically affect the norepinergic system in the DLPFC (Arnsten & Li, ; Berridge et al., ; Devilbiss & Berridge, ) cause a normalization of pathological P3 parameters in children with ADHD (Sanfins et al., ).…”

Section: Introductionmentioning

confidence: 80%

“…This is further supported by the observation of reduced left DLPFC activation during selective attention tasks (Christakou et al., ; Miao et al., ; Sanfins et al., ) and decreased P3 amplitudes in frontal areas during an auditory oddball paradigm in patients with attention deficit hyperactivity disorder (ADHD) (Janssen, Geladé, van Mourik, Maras, & Oosterlaan, ; Johnstone, Barry, & Clarke, ). Of note, pharmacological interventions in ADHD that typically affect the norepinergic system in the DLPFC (Arnsten & Li, ; Berridge et al., ; Devilbiss & Berridge, ) cause a normalization of pathological P3 parameters in children with ADHD (Sanfins et al., ). However, despite decades of intensive research on the role of the NC‐LE system and the fronto‐parietal network during selective attention the results still remain elusive.…”

Section: Introductionmentioning

confidence: 80%

Modulating auditory selective attention by non‐invasive brain stimulation: Differential effects of transcutaneous vagal nerve stimulation and transcranial random noise stimulation

Rufener

Geyer

Janitzky³

et al. 2018

Eur J of Neuroscience

View full text Add to dashboard Cite

Selective attention is a basic process required to maintain goal-directed behavior by appropriately responding to target stimuli and suppressing reactions to non-target stimuli. It has been proposed that auditory selective attention is linked to the activity of the locus coeruleus-norepinergic (LC-NE) system and a large-scale fronto-parietal cortical network, but there is still sparse causal evidence for these assumptions. By applying transcutaneous vagal nerve stimulation (tVNS) and transcranial random noise stimulation (tRNS) over the frontal cortex, we systematically assessed the involvement of these subcortical and cortical components in the regulation of auditory selective attention. Using a single-blinded, sham-controlled, within-subject design we analyzed online effects of tVNS and tRNS in 20 healthy participants during an auditory oddball paradigm. We show significant stimulation-dependent modulations of auditory selective attention on the behavioral and electrophysiological level. Compared to sham, tVNS increased the P3 amplitude, while tRNS reduced the reaction time to target stimuli. Moreover, both techniques reduced the P3 latency. Our data provide evidence for the functional relevance of the subcortical NE system in the regulation of neural resources that allows a phasic response to incoming target stimuli. They indicate that frontal cortex structures are crucially involved in the successful evaluation of the respective information. Moreover, our results are in favor of the LC-P3 hypothesis claiming the vital role of the NE system in auditory selective attention and in the generation of the P3. Of note, the effects of tVNS on auditory selective attention are comparable with those evoked by pharmacological interventions and invasive vagal nerve stimulation.

show abstract

“…For P300, prior studies have primarily focused on P300 amplitude, whereas P300 latency is less well studied. Although the majority of studies generally concern a small sample size, results seem to converge on a prolonged P300 latency in children with ADHD ( Sanfins et al, 2017 , Sunohara et al, 1997 , Tsai et al, 2012 , Yamamuro et al, 2016b ), albeit support for this seems to be less clear in adults ( Szuromi et al, 2011 ). Interestingly, a recent study by Chi and colleagues found that parents with ADHD offspring had longer P300 latencies ( Chi et al, 2019 ).…”

Section: Discussionmentioning

confidence: 97%

A multicenter effectiveness trial of QEEG-informed neurofeedback in ADHD: Replication and treatment prediction

Krepel

Egtberts

Sack

et al. 2020

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

Methylphenidate effects on P300 responses from children and adolescents

Cited by 5 publications

References 32 publications

Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event related potential

Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event related potential

Modulating auditory selective attention by non‐invasive brain stimulation: Differential effects of transcutaneous vagal nerve stimulation and transcranial random noise stimulation

A multicenter effectiveness trial of QEEG-informed neurofeedback in ADHD: Replication and treatment prediction

Contact Info

Product

Resources

About