Methylphenidate place conditioning in adolescent rats: An analysis of sex differences and the dopamine transporter

Cummins, Elizabeth D.; Griffin, Stephen B.; Burgess, Katherine C.; Peterson, Daniel J.; Watson, Bryce D.; Buendia, Matthew A.; Stanwood, Gregg D.; Brown, Russell W.

doi:10.1016/j.bbr.2013.09.036

Cited by 12 publications

(8 citation statements)

References 47 publications

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“…For the first time, we report that neonatal MA‐induced CWM impairments can be detected as early as P30, suggesting that the impact on striatal function is already affected at this age. The findings are consistent with other reports on adolescent behavior that implicate striatal function in conditioned place preference (Cummins et al, ). There are T‐maze studies in young rats that show disrupted T‐maze reversal learning at P26 in rats that received infusions of MK‐801 into the striatum (Watson & Stanton, ), and position habit deficits in a T‐maze in rats as young as P15 (Green & Stanton, ).…”

Section: Discussionsupporting

confidence: 93%

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment

Jablonski

Williams

Vorhees

2017

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In utero methamphetamine (MA) exposure leads to a range of adverse effects, such as decreased attention, reduced working-memory capability, behavioral dysregulation, and spatial memory impairments in exposed children. In the current experiment, preweaning Sprague-Dawley rats-as a model of third trimester human exposure-were administered the spin trapping agent, N-tert-butyl-α-phenylnitrone (PBN), daily prior to MA. Rats were given 0 (SAL) or 40 mg/kg PBN prior to each MA dose (10 mg/kg, 4× per day) from postnatal day (P) 6-15. Littermates underwent Cincinnati water maze, Morris water maze, and radial water maze assessment beginning on P30 (males) or P60 (females). Males were also tested for conditioned contextual and cued freezing, while females were trained in passive avoidance. Findings show that, regardless of age/sex, neonatal MA induced deficits in all tests, except passive avoidance. PBN did not ameliorate these effects, but had a few minor effects. Taken together, MA induced learning deficits emerge early and persist, but the mechanism remains unknown.

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Section: Discussionsupporting

confidence: 93%

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment

Jablonski

Williams

Vorhees

2017

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“…Considering there were no Sex × Days interactions, our results do not mesh well with pre-clinical research demonstrating a stronger response to methylphenidate in females compared to males. For example, adolescent female rats showed a more robust sensitization to a dose of methylphenidate compared to their male counterparts (Brown et al, 2012), although later research found no sex differences in conditioned-place preference using the same drug (Cummins et al, 2013). It is also noteworthy that these drug effects were moderated by the strain of rats and by the drug dose (Chelaru et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of â€œfood-addictionâ€

et al. 2014

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There is mounting evidence that many highly processed foods have addictive properties, and that some cases of compulsive overeating resemble an addiction disorder. While support for the Yale Food Addiction Scale (YFAS) as a valid diagnostic tool has been impressive and continues to increase, to date, no research has examined the food-addiction construct in response to an actual food stimulus, and in relation to direct measures of appetite and food consumption. As part of a larger community-based study of overeating in healthy adults who were predominately overweight and obese (aged 25–50 years), 136 participants completed the YFAS, of whom 23 met the diagnostic criteria for food-addiction. They took part in a 2-day, double-blind, cross-over, single-dose drug challenge using a psychomotor stimulant (methylphenidate) and placebo. Participants were first assessed on ratings of appetite and food cravings after holding and tasting their favorite snack food, after which they were able to eat all or part of the snack, as they wished. Three separate repeated-measures analysis-of-variance procedures were carried out, each with two between-subjects factors (Diagnosis: food-addiction vs. non-food addiction) and (Sex: male vs. female) and 1 within-subjects factor (Days: drug vs. placebo). As anticipated, for all three dependent variables, there was a significant main effect for Days with a response decrease from placebo to the drug condition. With respect to food cravings and appetite ratings, results indicated that the food addiction group had significantly higher scores on both variables. For food consumption, there was a significant Days × Diagnosis interaction whereby the food-addiction group showed no food-intake suppression across days compared to the non-food-addiction group who demonstrated a significant decrease in snack-food consumption with methylphenidate. The finding that the food-addiction group was resistant to the food-intake suppression typically induced by a dopamine agonist supports evidence of dopamine signaling-strength differences in individuals with compulsive overeating compared to those without this disorder. This represents the first demonstration that individuals defined by their food-addiction status have a unique pattern of food-intake following a pharmacologic challenge with such agents.

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“…Studies showed that female rats often required shorter training cycles and lower dosages of drugs ( including cocaine, morphine, nicotine, methylamphetamine, etc ) to acquire CPP compared to that in males (Russo et al , 2003b; Randall et al , 1998; Zakharova et al , 2009; Chen et al , 2003; Lenoir et al , 2015; Carroll and Anker, 2010). However, some studies showed no sex differences in the training cycle for CPP acquisition (Mathews and McCormick, 2007; Schindler et al , 2002; Hilderbrand and Lasek, 2014; Cummins et al , 2013; Bobzean et al , 2010). Such controversial findings can possibly be attributed to the type of drug, dosages of administration and age of the animals.…”

Section: Sex Differences In Drug Addictionmentioning

confidence: 99%

Sex differences in drug addiction and response to exercise intervention: From human to animal studies

Zhou

Zhao

Zhou

et al. 2016

Frontiers in Neuroendocrinology

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Accumulated research supports the idea that exercise could be an option of potential prevention and treatment for drug addiction. During the past few years, there has been increased interest in investigating of sex differences in exercise and drug addiction. This demonstrates that sex-specific exercise intervention strategies may be important for preventing and treating drug addiction in men and women. However, little is known about how and why sex differences are found when doing exercise-induced interventions for drug addiction. In this review, we included both animal and human that pulled subjects from a varied age demographic, as well as neurobiological mechanisms that may highlight the sex-related differences in these potential to assess the impact of sex-specific roles in drug addiction and exercise therapies.

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Methylphenidate place conditioning in adolescent rats: An analysis of sex differences and the dopamine transporter

Cited by 12 publications

References 47 publications

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment

Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of â€œfood-addictionâ€

Sex differences in drug addiction and response to exercise intervention: From human to animal studies

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Methylphenidate place conditioning in adolescent rats: An analysis of sex differences and the dopamine transporter

Cited by 12 publications

References 47 publications

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment

Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment

Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of â€œfood-addictionâ€

Sex differences in drug addiction and response to exercise intervention: From human to animal studies

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Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of â€œfood-addictionâ€