Methylphenidate Use for Emotional Dysregulation in Children and Adolescents with ADHD and ADHD and ASD: A Naturalistic Study

Ventura, Paolo; Giambattista, Concetta de; Trerotoli, Paolo; Cavone, Maddalena; Gioia, Alessandra Di; Margari, Lucia

doi:10.3390/jcm11102922

Cited by 8 publications

(4 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, without reaching significant differences probably due to the small size of this sample, the emotional DP showed a slightly higher score in the comorbid compared with the other clinical groups. Other authors have found that impaired emotional self‐regulation is more prevalent in youth with ADHD or/and autism (Bierens et al, 2023; Ventura et al, 2022) and that the shared association of these characteristics could predict social challenges (Jaisle et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of comorbidity of autism and ADHD and associated characteristics in school population: EPINED study

Canals,

Morales‐Hidalgo,

Voltas

et al. 2024

Autism Research

View full text Add to dashboard Cite

Autism and attention deficit hyperactivity disorder (ADHD) comorbidity in the school population have been understudied. This study estimates its prevalence considering both parents' and teachers' reports and clinical diagnosis. Sociodemographic, clinical, and cognitive data were compared by diagnostic groups: autism, ADHD, autism and ADHD, subthreshold autism spectrum disorder (ASD), subthreshold ADHD, and children without neurodevelopmental conditions. Following a two‐phase design, 3727 parents and teachers (1802 preschoolers, 1925 school‐age children) participated in the first phase. Subsequently, 781 participants underwent individual assessment for DSM‐5 diagnoses. The estimated prevalence of the comorbid diagnosis was 0.51% (0.28%–0.74%), with significant sex differences (0.16% girls, 0.89% boys). The cooccurrence of symptoms of autism and ADHD reported by parents or teachers was 3.2% and 2.6%, respectively. ADHD comorbidity was observed in 32.8% of autistic children and 31.4% of those with subthreshold ASD. ASD comorbidity was observed in 9.8% of children with ADHD and 5.7% of those with subthreshold ADHD. Comorbidity was reported by at least one informant in 95% of children. Only 15.8% of children with autism and ADHD had been previously diagnosed with both conditions. Early detection and accurate comorbidity diagnosis are crucial to address the clinical and socio‐educational needs of these children.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of comorbidity of autism and ADHD and associated characteristics in school population: EPINED study

Canals,

Morales‐Hidalgo,

Voltas

et al. 2024

Autism Research

View full text Add to dashboard Cite

show abstract

“…Regarding sensory dysregulation, pain perception in children and adolescents with ADHD is regulated with chronic MPH application (Wolff et al, 2016). Furthermore, the stimulant lessens anxiety (Snircova et al, 2016;Deslauriers et al, 2019;Jager et al, 2019), and has been shown to decrease emotional dysregulation in children with ADHD (Kutlu et al, 2017;Gamli and Tahiroglu, 2018;Ventura et al, 2022) potentially through reducing impulsivity (Gamli and Tahiroglu, 2018). MPH may lessen anxiety through the reduction of dopaminergic functional connectivity between the amygdala and the rostral anterior cingulate cortex (Berry et al, 2019).…”

Section: Chronic Administration Of Methylphenidatementioning

confidence: 99%

Emotional and sensory dysregulation as a possible missing link in attention deficit hyperactivity disorder: A review

Grossman

Avital²

2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Attention Deficit Hyperactivity Disorder (ADHD) is a common developmental disorder affecting 5-7% of adults and children. We surveyed the literature to examine ADHD through three pillars: developmental characteristics, symptomatology, and treatment strategies. Firstly, in terms of developmental characterstics, early life stress may increase the risk of developing ADHD symptoms according to animal models’ research. Secondly, the current core symptoms of ADHD are comprised of inattention, hyperactivity, and impulsivity. However, the up-to-date literature indicates individuals with ADHD experience emotional and sensory dysregulation as well, which early-life stress may also increase the risk of. Finally, we discuss the therapeutic benefits of methylphenidate on both the current core ADHD symptoms and the sensory and emotional dysregulation found in those with ADHD. In summation, we surveyed the recent literature to analyze (i) the potential role of early-life stress in ADHD development, (ii) the involvement of emotional and sensory dysregulation in ADHD symptomatology and finally, (iii) the therapeutic intervention with methylphenidate, aiming to reduce the potential effect of early life stress in ADHD, and mainly emotional and sensory dysregulation. The apparent but currently less recognized additional symptoms of emotional and sensory dysregulation in ADHD call for further investigation of these possible causes and thus increasing treatments efficacy in individuals with ADHD.

show abstract

“…These are products of emotional dysregulation (ED). Specifically, an inability to modulate emotional responses, resulting in extreme reactions of an internalizing or externalizing nature that are inappropriate for developmental age (Shaw et al, 2014;van Stralen, 2016;Ventura et al, 2022).…”

Section: Emotional Regulation and Adhdmentioning

confidence: 99%

“…Individual studies suggest that psychostimulant medication reduces emotional lability, irritability and aggressive behavior among children and adolescents with ADHD (e.g., Fernández de la Cruz et al, 2015;Suzer Gamli & Tahiroglu, 2018;Ventura et al, 2022). Nonetheless, not many systematic and meta-analytic reviews exist that examine this on a wider scale, those that do exist point towards methylphenidate 's efficacy (Conner et al, 2002;Pringsheim et al, 2015;Sorter et al, 2022).…”

Section: Methylphenidate and Emotional Regulationmentioning

confidence: 99%

Assessing therapeutic response to methylphenidate among children and adolescents with Attention-Deficit Hyperactivity Disorder: Narrative Review of its effects on emotional regulation, executive functions, and quality of life

Saveliev¹,

Shahar²

2022

Preprint

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) is a relatively common neurodevelopmental disorder that is often accompanied, in addition to its core symptoms, by a myriad of impairments in at least some emotion regulation (ER) and executive function (EF) abilities that together translate to quality of life (QoL) impairments. Stimulants and methylphenidate in particular, have been shown to alleviate both core ADHD symptoms and some of these accompanying impairments. The objective of this review is to highlight some of the recent systematic and meta-analytic literature that discusses methylphenidate’s therapeutic effects on ADHD symptoms, ER and EF as well as its impact on the QoL of children and adolescents with ADHD. Methylphenidate’s effects have shown to be significant in terms of symptom reduction (e.g, Standard mean difference (SMD) = 0.78), ER (e.g., Cohen’s d = 0.84) and QoL (e.g., SMD = 0.61) improvement with effect sizes ranging from medium to large while its effects on EFs were relatively modest (e.g., SMD = 0.21-0.62) with effect sizes ranging from small to medium. Specifically, working memory updating showing a low effect size (e.g., SMD = 0.26), inhibitory control ranging from low to moderate with the majority showing a low effect size (e.g., SMD = 0.29), and cognitive flexibility with a moderate effect size (e.g., SMD = 0.62). In addition, Methylphenidate has shown to be less likely to be discontinued due to inefficacy, displaying good acceptability, and without significant concerns of discontinuation due to intolerability when compared to placebo. In conclusion, Methylphenidate has been shown to reduce core symptoms, improve ER, EFs, and QoL to varying degrees with conceptual and methodological issues tapering off effects as well as conclusions.

show abstract

Methylphenidate Use for Emotional Dysregulation in Children and Adolescents with ADHD and ADHD and ASD: A Naturalistic Study

Cited by 8 publications

References 67 publications

Prevalence of comorbidity of autism and ADHD and associated characteristics in school population: EPINED study

Prevalence of comorbidity of autism and ADHD and associated characteristics in school population: EPINED study

Emotional and sensory dysregulation as a possible missing link in attention deficit hyperactivity disorder: A review

Assessing therapeutic response to methylphenidate among children and adolescents with Attention-Deficit Hyperactivity Disorder: Narrative Review of its effects on emotional regulation, executive functions, and quality of life

Contact Info

Product

Resources

About