Methylprednisolone Pulse Therapy in Dermatomyositis

Abstract

A high dose of methylprednisolone (pulse therapy) was given to 3 patients with uncontrolled dermatomyositis (DM) accompanied by severe muscle weakness. The effects of pulse therapy were compared with findings in 5 patients with severe DM who were treated with the usual dose of prednisolone (controls). The pulse therapy led to an improvement in the clinical symptoms in the 3 patients with uncontrolled DM, who were in danger of aspiration pneumonia. A rapid reduction in muscle enzyme levels in this group was also evident.

Prednisolone Pulse Therapy for Childhood Systemic Lupus erythematosus with Prominent Dermatomyositis

“…The kinet ics were comparable to those published by others using MPT [16] They have been observed only in patients receiving diuretics as well. However, the principal possibility of severe unwanted side-effects should be kept in mind.…”

“…Clinical and serologic improvement started after the first course of pulse therapy, and was remarkable during a second course. Basic treatment using oral pred nisolone is recommended.Chronic inflammatory connective tissue disorders like systemic lupus erythematosus (SLE) and dermatomyositis (DM) have been treated successfully using intravenous mé thylprednisolone pulse therapy (MPT) [2,4, 6, 8,11,16], We attempted to use predniso lone in a similar manner in a 10-year-old boy suffering from SLE with type VII DM according to Kreysel [7].Case Report 2 months before admission, a 10-year-old boy not iced progressive muscle weakness and tenderness. Malar rash preceded other features by 3 months.…”

High‐dose intravenous corticosteroid pulse therapy in alopecia areata: Own experience compared with the literature

“…The history of disease prior to intravenous pulse therapy was between 3 and 480 months in 23 patients. Average history of multifocal AA was 9.7 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), ophiasis-type AA 67.0 (5-180), and AA totalis/universalis 92.2 (5-480) months. Unsuccessful prior treatments included topical (class IV) or intralesional corticosteroids.…”

“…Oral corticosteroids do not usually affect long-term prognosis and are no longer used for chronic therapy of AA because of their side effects. Renewed interest in systemic corticosteroids has been sparked by reports on the successful use of suprapharmacologic dosages as pulse therapy in various autoimmune diseases without long-term side effects [3,9,10]. High-dose intravenous corticosteroid pulse therapy was first used to treat AA in 1975 by Burton and Shuster [1].…”

Hochdosis-Steroid-Pulstherapie

“…Die bisherigen Erfolge dieser Behandlungsform sind viel versprechend [60]. Da dieses Therapieregime insbesondere bei der juvenilen Dermatomyositis von zahlreichen Nebenwirkungen begleitet ist und zudem nur ca.…”