Methysergide in Mania

Coppen, Alec; Prange, A.J.; Whybrow, PeterC.; Noguera, R. Pérez; Páez, JA

doi:10.1016/s0140-6736(69)92697-x

Cited by 35 publications

(4 citation statements)

References 24 publications

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“…A similar effect was reported by Haskovec and Soucek (1968) who found improvement in 8 of 10 patients. However, in the only double-blind study of methysergide in mania, Coppen et al (1969) gave comparable doses, but found, if anything, that their patients deteriorated.…”

Section: Methysergidementioning

confidence: 95%

Biogenic Amines and Affective Disorders

Luchins¹

1976

Int Pharmacopsychiatry

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The evidence linking biogenic amines and affective disorders is critically reviewed. Surveyed are studies on the level of biogenic amines and their metabolites in the brain, blood, urine and cerebrospinal fluid of patients with affective conditions; the effects of biogenic amine precursors, depletors and blockers on affective states and the action of present methods of treatment of these disorders on the level of biogenic amines. Reference is also made to the existence of various disease states where abnormalities of biogenic amines exist in the absence of affective disorders. The review fails to uncover convincing evidence that affective disorders are related to abnormal levels of biogenic amines. Reasons are outlined why the 'catecholamine hypothesis' and related theories can neither be proven nor disproven with the available techniques.

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Section: Methysergidementioning

confidence: 95%

Biogenic Amines and Affective Disorders

Luchins¹

1976

Int Pharmacopsychiatry

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“…This interpretation runs counter to the view that mania is due to over-activity of 5-HT pathways and that blockade of 5-HT receptors with methysergide is a specific treatment for mania (Dewhurst, 1969). Unfortunately for this view Coppen, Prange & Whybrow (1969) failed to confirm that methysergide had any anti-manic activity, on the contrary it seemed to make matters worse.…”

Section: -Hydroxytryptamine and Dopamine Pathways In Mania: A Pilot mentioning

confidence: 98%

5‐Hydroxytryptamine and dopamine pathways in mania: a pilot study of fenfluramine and pimozide [letter].

Cookson¹,

Silverstone²

1976

Brit J Clinical Pharma

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“…On the other hand, Fieve et al (1969) in an open sequential controlled study found that methysergide did not produce dramatic effects, while lithium was effective after a mean duration of 10-13 days. Furthermore, Coppen et al (1969) in a double-blind, placebo controlled, sequential study with methysergide 6 mg followed by placebo each for 8 days, found that methysergide was not effective in controlling any of the manic symptoms. At the same time, another antiserotonin agent, cinanserin has been reported to be useful in the treatment of manic (Kane, 1970;Holden et al, 1971;Itil et al, 1971), but not schizophrenic patients.…”

Section: Serotoninmentioning

confidence: 99%

Treatment Approaches to Mania

Ananth¹

1976

Int Pharmacopsychiatry

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Treatment of manic episodes is an urgency because of the lack of insight and excessive psychomotor activity. Over the past two decades various new modes of pharmacological treatment of this condition has been reported. Along with them, biochemical findings in manic patients have been exhaustively investigated. Etiologically based pharmacological treatment of manic episodes will help us therapeutically in improving the condition of the patient and scientifically, to confirm or explore biochemical basis of manic episodes. The new innovative approaches for the treatment of manic episodes need to be applied in treating therapy-resistant patients. Included in this paper are treatment approaches based on norepinephrine, dopamine, acetylcholine, serotonin, γ-aminobutyric acid and permissive hypothesis, peripheral autonomic imbalance, endocrine abnormalities, electrolyte disturbances, paradoxical response, and cyclic AMP. In addition, use of antidepressants and pyrotherapy is described.

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Methysergide in Mania

Cited by 35 publications

References 24 publications

Biogenic Amines and Affective Disorders

Biogenic Amines and Affective Disorders

5‐Hydroxytryptamine and dopamine pathways in mania: a pilot study of fenfluramine and pimozide [letter].

Treatment Approaches to Mania

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