Metilfenidato: Propiedades, aplicaciones y controversias

Calvi, Juan Pablo Quintanilla; Cornejo, Guillermo Saúl Escobar

doi:10.36901/psicologia.v12i1.1479

Cited by 1 publication

(1 citation statement)

References 32 publications

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“…Some studies suggest that the increase in dopamine induced by methylphenidate could have an antioxidant effect since dopamine can scavenge free radicals [45,48]. Other studies indicate that methylphenidate would have protective properties by sequestering toxins and toxic metabolites of dopamine through the redistribution of the vesicular monoamine transporter type 2 (VMAT2) [49][50][51][52]. Alternatively, the beneficial effect of methylphenidate would be exerted by protecting cells against neurotoxic metabolites [53] or by increasing the activity of superoxide dismutase (SOD) and CAT.…”

Section: Discussionmentioning

confidence: 99%

Changes in Cortisol and in Oxidative/Nitrosative Stress Indicators after ADHD Treatment

Garre-Morata,

Haro,

Villén

et al. 2023

Preprint

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ADHD, one of the most prevalent diseases during childhood, we still do not know its precisely origin, although oxidative/nitrosative stress and the hypothalamic-pituitary-adrenal axis are suggested contributors. Methylphenidate, among others, is the main drug used in these patients, but its effects on relevant markers and structures remain unclear. This study, involving 59 patients diagnosed with ADHD according to DSM-5 criteria, aimed to assess changes in cortisol levels (using cortisol awakening response, CAR) and oxidative/nitrosative status with the treatment. Blood samples before and 3 months after treatment with methylphenidate were used to measure oxidative and inflammatory markers, and the endogenous antioxidant activity, while saliva samples tracked cortisol awakening response (CAR). The results show a treatment-related improvement in the redox profile, with the reduction of advanced oxidation protein products (AOPP), lipid peroxidation (LPO), and nitrite plus nitrate (NOx) levels, and the increase of the enzymatic activities of glutathione reductase (GRd) and catalase (CAT). Moreover, the area under the curve (AUC) of CAR increased significantly, indicating increased reactivity of the HPA axis. These result support by the first time the involvement of the endogenous antioxidant system in the pathophysiology of ADHD.

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