Metoclopramide and prochlorperazine do not decrease propofol hypnotic requirements

Abstract

SummaryOne hundred patients scheduled for minor surgery were given either saline, metoclopramide 0.1 mg.kg-' or 0.2mg.kg-', or prochlorperazine 0.1 mg.kg-' or 0.2 mg.kg-' before induction of anaesthesia with a fixed rate infusion of propofol. Neither metoclopramide nor prochlorperazine reduced the induction dose of propofol. The possibility that these agents increased the induction dose could not be excluded.