Métodos diagnósticos de la miastenia grave seronegativa

T, Blanco-Hernández; Navarre-Gimeno, A; Brocalero-Camacho, A; Cervelló-Donderis, A; López-Trigo, J; Ortiz-Sánchez, P; Sancho-Rieger, J

doi:10.33588/rn.4606.2007580

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patient had a negative test for antibodies and electromyography. RNS testing was negative; however, the literature suggests that only 70% of patients will be positive with RNS testing [6] . Pyridostigmine improved the patient's symptoms and allowed weaning in our case.…”

Section: Guillainmentioning

confidence: 94%

Empirical pyridostigmine in a patient with difficult weaning from mechanical ventilation after traumatic brain injury

Siddiqui,

Strandvik,

El-Menyar

et al. 2024

European Journal of Case Reports in Internal Medicine

View full text Add to dashboard Cite

We present a 30-year-old male who sustained a mild traumatic brain injury and then was intubated due to deterioration of consciousness. A head CT scan revealed mild brain oedema, a fractured nasal bone and mild left thoracic wall haematoma. Despite complete clinical and radiological normalisation within 36 hours, he failed to wean off the ventilator. The patient was found to have subtle bulbar manifestations including dysphonia, dysarthria, and dysphagia, with recurrent left lung collapse. He responded to an empirical pyridostigmine trial despite negative biochemical tests for myasthenia gravis (MG). The patient was weaned successfully from the ventilator, transferred to a long-term care facility, and then discharged home. Classic symptoms and signs of a disease may be absent, but the presence of dysarthria, dysphagia, transient vocal cord palsy, nasal speech, absent gag reflex and respiratory failure in difficult-to-wean patients, with no definitive diagnosis, may warrant an empirical trial of therapy for suspected MG and for the benefit of any doubt.

show abstract

Section: Guillainmentioning

confidence: 94%