Metronidazole and tinnitus: A potential side effect?

O’Donnell, Katherine; Barker, D

doi:10.1038/sj.bdj.2016.218

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…However, antibiotics have side effects, e.g., 1-2% of individuals have allergy to penicillins [42], metronidazole was discussed having ototoxicity [43] and combined with penicillin it may cause nausea and diarrhea [44]. Moreover, the global problem of development of resistance associated with the consumption of antibiotics [45] demands a well indicated and very restricted use of these drugs [46].…”

Section: Discussionmentioning

confidence: 99%

Microbiological analysis and the outcomes of periodontal treatment with or without adjunctive systemic antibiotics—a retrospective study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Microbiological analysis and the outcomes of periodontal treatment with or without adjunctive systemic antibiotics—a retrospective study

et al. 2018

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“…Antibiotics (aminoglycosides, tetracycline, macrolides, quinolones, vancomycin, metronidazole) 159–164 …”

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Tinnitus: Are There Opportunities for Improvement?

Grundfast

Jamil

2022

Otolaryngol.--head neck surg.

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Objective To review current information about diagnosis and management of tinnitus aiming to identify opportunities for achieving a cost-effective, efficient, evidence-based approach that meets the needs of tinnitus sufferers. Data Sources PubMed/MEDLINE. Review Methods In total, 249 relevant published reports were reviewed. Pertinent keywords and MeSH terms identified reports via PubMed and EMBASE. Acknowledged experts were consulted on ways to improve tinnitus management. Conclusions There may be opportunities to improve evaluation and management of patients with tinnitus using modern modes of communication and a multidisciplinary therapeutic approach. Implications for Practice Tinnitus can adversely affect quality of life while being time-consuming and costly to evaluate and manage. Based on both personal experience and the reports of others, patients with tinnitus who choose to see a physician primarily want to know two things: (1) that the tinnitus that is so distressing will not remain at the same level of severity forever and (2) that something can be done to help cope with the tinnitus that is so annoying. Recent advancements in internet communications, social media, information technology, artificial intelligence, machine learning, holistic medical care, mind-body integrative health care, and multidisciplinary approaches in medical therapeutics may be possibly making new ways of meeting the needs of patients with tinnitus.

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“…Only 3% of the CPs identified the inappropriate indication of metronidazole and all refused to dispense the medication. However, 97% of the CPs did dispense the drug, putting the pediatric patient at risk of developing the side effects of the drug which include gastrointestinal disturbances, oral mucositis, anorexia, thrombocytopenia, rash, and jaundice [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Community Pharmacists’ Competences in Identifying and Resolve Drug-Related Problems in a Pediatric Prescription Using the Simulated Patient Method

et al. 2022

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Background: Drug-related problems (DRPs) are a global issue that impacts the efficacy and safety of the therapy, and pediatric patients are considered to be more vulnerable to DRPs, thus requiring more attention. Community pharmacists (CPs) are in a position that allow them to identify and alleviate these DRPs. Objectives: This study evaluated the ability of CPs in identifying and resolving DRPs in a pediatric prescription. Methods: A cross-sectional study was carried out in 235 community pharmacies to evaluate the ability of CPs working in the Khartoum locality to identify DRPs in a pediatric prescription and how they intervene to resolve these problems. Fifth-final year B. Pharm. Students were selected and trained to act as simulated patients (SPs) for this study. The visits were performed by using a simulated prescription that contains three different types of DRPs. The information obtained from the visits was documented immediately by the SPs after leaving the pharmacy in a data collection form. Results: All planned SPs visits were completed. Of the 235 community pharmacies, only 50 (21.3%) CPs were able to identify at least one of the DRPs. The most common type of DRP identified was the wrong duration of the treatment 19%, followed by the wrong dose 4%. The interventions made by CPs to mitigate the identified DRPs included recalculation and correction of the dose according to weight, which was made by 10 CPs, and correction of the duration, which was done by 45 CPs. None of the CPs who identified the presented DRPs communicated with the physician or referred the SP to the prescriber. The average dispensing time of the CPs was 68.18 ± 36.1 s. Conclusions: The majority of the CPs in the Khartoum locality were unable to identify DRPs in a pediatric prescription. Correction of the dose and duration of treatment were from the attempts of CPs to resolve DRPs. However, no collaboration was observed between CPs and physicians. In general, the practice of CPs in Khartoum locality in this area requires substantial improvement.

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Metronidazole and tinnitus: A potential side effect?

Cited by 6 publications

References 8 publications

Microbiological analysis and the outcomes of periodontal treatment with or without adjunctive systemic antibiotics—a retrospective study

Microbiological analysis and the outcomes of periodontal treatment with or without adjunctive systemic antibiotics—a retrospective study

Evaluation and Management of Tinnitus: Are There Opportunities for Improvement?

Evaluation of Community Pharmacists’ Competences in Identifying and Resolve Drug-Related Problems in a Pediatric Prescription Using the Simulated Patient Method

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