Metronidazole-functionalized iron oxide nanoparticles for molecular detection of hypoxic tissues

Filippi, Miriam; Nguyen, Dinh-Vu; Garello, Francesca; Perton, Francis; Bégin‐Colin, Sylvie; Felder‐Flesch, Delphine; Power, Laura; Scherberich, Arnaud

doi:10.1039/c9nr08436c

Cited by 25 publications

(12 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[129] Importantly, microchips can also precisely control the spatiotemporal oxygen distribution in 3D cell cultures, [130][131][132][133] becoming essential in investigating the hypoxic microenvironment which is a crucial pathological feature in many diseases, including cancer. [134][135][136][137][138] Through microfluidics, hypoxic tissue models can be produced by recreating physiologically-relevant low and cycling oxygen levels that are not attainable in traditional macroscopic cell culture. [130,131] In a recent study, breast tumor spheroids were monitored over time while being exposed to an anticancer treatment and time-varying oxygen profiles switching between 0% and 10% O 2 , providing important insights into cell response to changing oxygenation states of the environment.…”

Section: Replication Of the Cell Microenvironmentmentioning

confidence: 99%

Microfluidic Tissue Engineering and Bio‐Actuation

et al. 2022

Self Cite

View full text Add to dashboard Cite

Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic and living materials and have the potential to self‐assemble, regenerate, work autonomously, and interact safely with other species and the environment. Cells require a sufficient exchange of nutrients and gases, which is guaranteed by convection and diffusive transport through liquid media. The functional development and long‐term survival of biological tissues in vitro can be improved by dynamic flow culture, but only microfluidic flow control can develop tissue with fine structuring and regulation at the microscale. Full control of tissue growth at the microscale will eventually lead to functional macroscale constructs, which are needed as the biological component of soft bio‐hybrid technologies. This review summarizes recent progress in microfluidic techniques to engineer biological tissues, focusing on the use of muscle cells for robotic bio‐actuation. Moreover, the instances in which bio‐actuation technologies greatly benefit from fusion with microfluidics are highlighted, which include: the microfabrication of matrices, biomimicry of cell microenvironments, tissue maturation, perfusion, and vascularization.

show abstract

Section: Replication Of the Cell Microenvironmentmentioning

confidence: 99%

Microfluidic Tissue Engineering and Bio‐Actuation

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The change in the R 2 relaxivity of hypoxic MCF‐7 tumor cells treated with metronidazole‐functionalized dendronized IONs (metro‐NPs) was about 170%, while the relaxivity change of ASCs treated with the same NPs was nearly 100%. Such a difference in the relaxivity variation percentage may be used to distinguish normoxia cells from tumor hypoxia cells (Filippi et al, 2019). In another report, the Tang group constructed a rationally designed hypoxia‐targeting nanoprobe with a high molecular weight, G3(DTPA‐Gd)‐SA (Figure 7).…”

Section: Applications Of Dendritic Nano‐scale Systems In Cancer Diagnmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

173

View full text Add to dashboard Cite

Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

show abstract

“…Filippi et al. [ 55 ] used a nitroimidazole derivative, metronidazole, to functionalize dendrites to encapsulate iron oxide nanoparticles which can thus effectively label hypoxic tumor cells and greatly enhance their MRI signals in vitro.…”

Section: Hypoxia‐responsive Strategiesmentioning

confidence: 99%

Designing Hypoxia‐Responsive Nanotheranostic Agents for Tumor Imaging and Therapy

Zhou

Qin

Chen

2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Hypoxia, a common feature of most solid tumors, plays an important role in tumor proliferation, metastasis, and invasion, leading to drug, radiation, and photodynamic therapy resistance, and resulting in a sharp reduction in the disease‐free survival rate of tumor patients. The lack of sufficient blood supply to the interior regions of tumors hinders the delivery of traditional drugs and contrast agents, interfering with their accumulation in the hypoxic region, and preventing efficient theranostics. Thus, there is a need for the fabrication of novel tumor theranostic agents that overcome these obstacles. Reports, in recent years, of hypoxia‐responsive nanomaterials may provide with such means. In this review, a comprehensive description of the physicochemical and biological characteristics of hypoxic tumor tissues is provided, the principles of designing the hypoxia‐responsive tumor theranostic agents are discussed, and the recent research into hypoxia‐triggered nanomaterials is examined. Additionally, other hypoxia‐associated responsive strategies, the current limitations, and future prospects for hypoxia‐responsive nanotheranostic agents in tumor treatment are discussed.

show abstract

Metronidazole-functionalized iron oxide nanoparticles for molecular detection of hypoxic tissues

Abstract: Functionalization of dendronized iron oxide nanoparticles with the bioreductive compound metronidazole for magnetic resonance imaging of hypoxic tissues.

Cited by 25 publications

References 54 publications

Microfluidic Tissue Engineering and Bio‐Actuation

Microfluidic Tissue Engineering and Bio‐Actuation

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Designing Hypoxia‐Responsive Nanotheranostic Agents for Tumor Imaging and Therapy

Contact Info

Product

Resources

About