Metronomic weekly paclitaxel in advanced unresectable esophageal cancer

Noronha, Vanita; Patil, Vijay; Bhosale, Bharat; Joshi, Amit; Purandare, Nilendu; Prabhash, Kumar

doi:10.4103/0019-509x.117020

Cited by 11 publications

(1 citation statement)

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“…After a median of 11 cycles, 71% of 51 patients had improvement in dysphagia. Overall response was 49%, with median progression-free survival of 4.7 months [203]. A different study retrospectively evaluated the efficacy of metronomic capecitabine in pretreated upper gastrointestinal tract cancers including patients with esophagogastric and pancreaticobiliary tumors with 31% of patients achieving clinical benefit [204].…”

Section: Resultsmentioning

confidence: 99%

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience

Şimşek

Esin

Yalçın

2019

Journal of Oncology

102

100

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Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades. To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts’ immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells. Its better toxicity profile, lower cost, and easier use are main advantages over conventional therapies. The evidence of metronomic chemotherapy for personalized medicine is growing, starting with unfit elderly patients and also for palliative treatment. The literature reviewed in this article mainly demonstrates that metronomic chemotherapy is advantageous for selected patients and for certain types of malignancies, which make it a promising therapeutic approach for filling in the gaps. More clinical studies are needed to establish a solidified role for metronomic chemotherapy with other treatment models in modern cancer management.

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Section: Resultsmentioning

confidence: 99%