METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis
Yiwen Zhang,
Yiping Kong,
Wenjie Zhang
et al.
Abstract:Background
Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteome change. METTL3 is the pivotal methyltransferase of N6-methyladenosine (m6A) that is recently proved to exert a crucial role in osteoblast differentiation. This study aims to investigate the role of METTL3 in osteoblast ribosome biogenesis in periodontitis progression.
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