METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification

Wang, Yang; Zhang, Gang; Gao, Yan; Zhang, Xuemei; Qi, Hongbo

doi:10.1016/j.yexcr.2024.113990

Experimental Cell Research

2024

DOI: 10.1016/j.yexcr.2024.113990

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METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification

Yang Wang,

Gang Zhang,

Yan Gao

et al.

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2024

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Cited by 2 publications

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N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Cui,

Li,

Huang

et al. 2024

Immunity Inflam & Disease

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BackgroundN6‐methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing a pivotal role in various biological functions. Its significance in female reproductive development and associated diseases has recently become a focal point of research.ObjectiveThis review aims to consolidate current knowledge of the role of m6A modification in female reproductive tissues, emphasizing its regulatory dynamics, functional significance, and implications in reproductive health and disease.MethodsA comprehensive analysis of recent studies focusing on m6A modification in ovarian development, oocyte maturation, embryo development, and the pathogenesis of reproductive diseases.Resultsm6A modification exhibits dynamic regulation in female reproductive tissues, influencing key developmental stages and processes. It plays critical roles in ovarian development, oocyte maturation, and embryo development, underpinning essential aspects of reproductive health. m6A modification is intricately involved in the pathogenesis of several reproductive diseases, including polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and endometriosis, offering insights into potential molecular mechanisms and therapeutic targets.ConclusionThe review highlights the crucial role of m6A modification in female reproductive development and related diseases. It underscores the need for further research to explore innovative diagnostic and therapeutic strategies for reproductive disorders, leveraging the insights gained from understanding m6A modification's impact on reproductive health.

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N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Cui,

Li,

Huang

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

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MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis

Li,

He,

Zheng

et al. 2024

Biol Direct

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METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification

Cited by 2 publications

References 33 publications

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis

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METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification

Cited by 2 publications

References 33 publications

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis

Contact Info

Product

Resources

About

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases