2021
DOI: 10.1016/j.ymthe.2021.01.019
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METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8-mediated neutrophil infiltration

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Cited by 110 publications
(75 citation statements)
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“…The activation of Wnt/β-catenin signaling has been reported plenty of times in DLBCL. For instance, GPNMB was suggested to be an oncogene in DLBCL, revealed by partly activating the Wnt/β-catenin signaling via YAP1 [ 44 ]. The downregulation of another pair of oncogenes in DLBCL, FBN1, and TIMP1 resulted in the downregulation of Wnt3, GSK3β, β-catenin, c-Myc, and cyclin D1, suggesting the inactivation of Wnt/β-catenin signaling [ 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…The activation of Wnt/β-catenin signaling has been reported plenty of times in DLBCL. For instance, GPNMB was suggested to be an oncogene in DLBCL, revealed by partly activating the Wnt/β-catenin signaling via YAP1 [ 44 ]. The downregulation of another pair of oncogenes in DLBCL, FBN1, and TIMP1 resulted in the downregulation of Wnt3, GSK3β, β-catenin, c-Myc, and cyclin D1, suggesting the inactivation of Wnt/β-catenin signaling [ 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, neutrophils and activated memory CD4 T cells were more highly expressed in CD and UC tissues than in normal tissues, but no significant differences in the T cell types or neutrophils exist between the two m 6 A modification patterns, indicating that m 6 A regulators may influence inflammation development primarily by recruiting macrophages. METTL3 deficiency increases the secretion of IL8 and elevates the recruitment of neutrophils (He et al, 2021). In our study, IL8 expression in m 6 Acluster1 was increased, and expression of IL15, IL16, and IL18 was upregulated in m 6 Acluster2, suggesting that m 6 A methylation modification may change mucosal inflammatory factors in IBD.…”
Section: Discussionsupporting
confidence: 53%
“…METTL3 and METTL14 were the hub nodes of the m6A writers, and the hub node of the reader was HNRNPA2B1. Recently, He et al ( He et al, 2021 ) demonstrated that METTL3 regulates tumor growth by cooperating with YTHDF2. This is to some extent a validation of our prediction.…”
Section: Resultsmentioning
confidence: 99%