Mexiletine clearance during peritoneal dialysis [letter]

Guay,; Meatherall, RC; Ferguson, Ian; Smith, Hazel; Light, Bruce

doi:10.1111/j.1365-2125.1985.tb02732.x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Mexiletine1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1986

1991

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 8 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the HD clearance of mexiletine has not been directly determined, there were no significant changes from normal pharmacokinetic parameters in patients studied either intradialytically or on an off-dialysis day (40). PD clearance is negligible (42,43).…”

Section: Mexiletinementioning

confidence: 96%

Antiarrhythmic Medications

Gehr

Sica

1990

Seminars in Dialysis

View full text Add to dashboard Cite

Section: Mexiletinementioning

confidence: 96%

Antiarrhythmic Medications

Gehr

Sica

1990

Seminars in Dialysis

View full text Add to dashboard Cite

M

Seyffart¹

1991

Drug Dosage in Renal Insufficiency

View full text Add to dashboard Cite

Clinical Pharmacokinetics of Mexiletine

Grech-Bélanger

1986

Clinical Progress in Electrophysiology and Pacing

View full text Add to dashboard Cite

GRECH-BELANGER, O: Clinical pharmacokinetics of mexiletine. The pharmacokinetics of mexiletine and the factors that have been shown to modify its disposition are reviewed. The clinical significatice of the modifications observed is discussed. Mexiletine is well absorbed from the gut and the bioavailability is 80-88%. The volume of distribution is large (5-9 L/kg) and 70% of the drug is bound to serum proteins. The elimination half-life varies between 6-12 hours. Concomitant administration of atropine, metoclopramide, gastric acids, narcotic analgesics and cimetidine modify the peak concentrations of mexiletine and the time required to attain these concentrations. Rifi:impicin, phenytoin, and cigarette smoking shorten the elimination half-life and increase the clearance. The volume of distribution of mexiletine is increased to the acute phase of myocardial infarction, whereas its elimination half-life is increased in both cardiac failure and cirrhosis. Factors modifying the elimination, unlike those affecting the absorption characteristics, of mexiletine are of clinical importance and may require a modification of the dosage regitiien.

show abstract

Mexiletine clearance during peritoneal dialysis [letter]

Cited by 8 publications

References 6 publications

Antiarrhythmic Medications

Antiarrhythmic Medications

M

Clinical Pharmacokinetics of Mexiletine

Contact Info

Product

Resources

About