2022
DOI: 10.1088/1361-6528/ac56f3
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Mg/Al-LDH as a nano-adjuvant for pertussis vaccine: a evaluation compared with aluminum hydroxide adjuvant

Abstract: Background: Layered double hydroxide (LDH) has been demonstrated as a highly efficient antigen platform to induce effective and durable immune response. However, whether LDH nanoparticles could act as an adjuvant for pertussis vaccines is still unknown. Here we evaluated the potential of Mg/Al-LDH as a nano-adjuvant to improve immune response against pertussis and compared it with commercial aluminum hydroxide (AH) adjuvant. Method: The Mg/Al-LDH nanoparticles were synthesized by a hydrothermal reaction. The m… Show more

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Cited by 12 publications
(5 citation statements)
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“…Layered dihydroxide (LDH) is an efficient adjuvant platform that has been demonstrated to induce effective and persistent immune responses. Mg/Al-LDH, as a nanoadjuvant, significantly improved pertussis humoral immune responses [ 100 ]. Poly [di (sodium carboxylatophenoxy) phosphazene] (PCPP) can be used as a novel mucosal adjuvant for aP.…”
Section: Critical Needs For New Pertussis Vaccinesmentioning
confidence: 99%
“…Layered dihydroxide (LDH) is an efficient adjuvant platform that has been demonstrated to induce effective and persistent immune responses. Mg/Al-LDH, as a nanoadjuvant, significantly improved pertussis humoral immune responses [ 100 ]. Poly [di (sodium carboxylatophenoxy) phosphazene] (PCPP) can be used as a novel mucosal adjuvant for aP.…”
Section: Critical Needs For New Pertussis Vaccinesmentioning
confidence: 99%
“…Nano-adjuvants, such as the ginsenosides and oil-in-water nanoemulsions in the hepatitis B vaccine, display stronger humoral and cellular immune-inducing effects compared to traditional aluminum salt adjuvants [ 92 ]. Moreover, the Mg/Al-LDH adjuvant, synthesized from layered double hydroxide (LDH) and Mg/Al for the pertussis vaccine, elicits a milder inflammatory response at the injection site than that of aluminum hydroxide (AH) while demonstrating a superior safety profile [ 93 ]. Nano-adjuvants hold interest due to their small particle size, targeting ability, low toxicity, prolonged immune response and their capacity to elicit organism-specific cellular and humoral immunity [ 94 ].…”
Section: Discussionmentioning
confidence: 99%
“…Li et al 2022 reported a major immune response, with LDH as adjuvant when compared to aluminum hydroxide. Despite this, LDH produced a slighter inflammatory response at the injection site [21,22]. Our group has recently reported a systematic synthesis and characterization protocol for LDH and confirmed that LDH acted as adjuvant for BSA as model antigen [19].…”
Section: Introductionmentioning
confidence: 88%