Mg-based bulk metallic glasses: A review of recent developments

Bin, Shi Jie Bryan; Fong, Kai Soon; Chua, Beng Wah; Gupta, Manoj

doi:10.1016/j.jma.2021.10.010

Cited by 35 publications

(6 citation statements)

References 112 publications

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“…Here, copper mold casting, among the most effective procedures, was used to prepare corrosion-resistant BMG. However, the composition control, alongside the ability to produce customized implants, has proved challenging [ 34 ]. As a new generation technology for the development of BMG [ 35 ], additive manufacturing provides a promising, economical and scalable technique.…”

Section: Resultsmentioning

confidence: 99%

Combining Mg–Zn–Ca Bulk Metallic Glass with a Mesoporous Silica Nanocomposite for Bone Tissue Engineering

et al. 2022

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Mg–Zn–Ca bulk metallic glass (BMG) is a promising orthopedic fixation implant because of its biodegradable and biocompatible properties. Structural supporting bone implants with osteoinduction properties for effective bone regeneration have been highly desired in recent years. Osteogenic growth peptide (OGP) can increase the proliferation and differentiation of mesenchymal stem cells and enhance the mineralization of osteoblast cells. However, the short half-life and non-specificity to target areas limit applications of OGP. Mesoporous silica nanoparticles (MSNs) as nanocarriers possess excellent properties, such as easy surface modification, superior targeting efficiency, and high loading capacity of drugs or proteins. Accordingly, we propose a system of combining the OGP-containing MSNs with Mg–Zn–Ca BMG materials to promote bone regeneration. In this work, we conjugated cysteine-containing OGP (cgOGP, 16 a.a.) to interior walls of channels in MSNs and maintained the dispersity of MSNs via PEGylation. An in vitro study showed that metal ions released from Mg–Zn–Ca BMG promoted cell proliferation and migration and elevated alkaline phosphatase (ALP) activity and mineralization. On treating cells with both BMG ion-containing Minimum Essential Medium Eagle-alpha modification (α-MEM) and OGP-conjugated MSNs, enhanced focal adhesion turnover and promoted differentiation were observed. Hematological analyses showed the biocompatible nature of this BMG/nanocomposite system. In addition, in vivo micro-computed tomographic and histological observations revealed that our system stimulated osteogenesis and new bone formation around the implant site.

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Section: Resultsmentioning

confidence: 99%

Combining Mg–Zn–Ca Bulk Metallic Glass with a Mesoporous Silica Nanocomposite for Bone Tissue Engineering

et al. 2022

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“…The component interaction in RTX intermetallic systems (R = rare earth metal; T = transition metal; X = other metal) results in many ternary compounds with recurrent stoichiometries in different concentration ranges. These compounds have been widely studied both for their applicative and fundamental properties [1][2][3][4][5][6][7][8][9][10][11][12], and they represent an ever-growing database for studying structural relationships, aiming for simplified descriptions and rational generalizations.…”

Section: Introductionmentioning

confidence: 99%

{Ca, Eu, Yb}23Cu7Mg4 as a Step towards the Structural Generalization of Rare Earth-Rich Intermetallics

Solokha,

Freccero,

De Negri

2024

Crystals

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The R23Cu7Mg4 (R = Ca, Eu) intermetallics, studied by single-crystal X-ray diffraction, were found to be isostructural with the Yb23Cu7Mg4 prototype (hP68, k4h2fca, space group P63/mmc), forming a small group inside the bigger 23:7:4 family, otherwise adopting the hP68-Pr23Ir7Mg4 crystal structure. The observed structural peculiarity is connected with the divalent character of the R component and with a noticeable volume contraction, resulting in the clear clustering of title compounds inside the whole 23:7:4 family. The occurrence of fragments typical of similar compounds, particularly Cu-centered trigonal prisms and Mg-centered core–shell polyicosahedral clusters with R at vertices, induced the search of significant structural relationships. In this work, a description of the hexagonal crystal structure of the studied compounds is proposed as a linear intergrowth along the c-direction of the two types of slabs, R10CuMg3 (parent type: hP28-kh2ca, SG 194) and R13Cu6Mg (parent type: hR60-b6a2, SG 160). The ratio of these slabs in the studied structure is 2:2 per unit cell, corresponding to the simple equation, 2 × R10CuMg3 + 2 × R13Cu6Mg = 2 × R23Cu7Mg4. This description assimilates the studied compounds to the {Ca, Eu, Yb}4CuMg ones, where the same slabs (of p3m1 layer symmetry) are stacked in a different way/ratio and constitutes a further step towards a structural generalization of R-rich ternary intermetallics.

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“…Despite the numerous advantages of bulk metallic glasses, very few have made it to the manufacturing stage. This is because the synthesis of bulk metallic glasses (BMGs) is extremely challenging, owing to the need for extremely high cooling rates of ~10 4 -10 5 • C/s [6]. Different densification methods have been proposed to obtain BMGs, including warm extrusion [7,8], equal channel angular extrusion [9], selective laser sintering [10], and spark plasma sintering [11].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Mechanical and Biocorrosion Response of a MgZnCa Bulk Metallic Glass through Variation in Spark Plasma Sintering Time

Bryan,

Fong,

Wah

et al. 2023

Metals

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Development of metallic glasses is hindered by the difficulties in manufacturing bulk parts large enough for practical applications. Spark plasma sintering (SPS) has emerged as an effective consolidation technique in the formation of bulk metallic glasses (BMGs) from melt-spun ribbons. In this study, Mg65Zn30Ca5 melt-spun ribbons were sintered at prolonged sintering times (15 min to 180 min) via SPS under a pressure of 90 MPa and at a temperature of 150 °C (which is below the crystallization temperature), to provide an insight into the influence of sintering time on the consolidation, structural, and biodegradation behavior of Mg-BMGs. Scanning Electron Microscopy was used to characterize the microstructure of the surface, while the presence of the amorphous phase was characterized using X-ray diffraction and Electron Backscatter Diffraction. Pellets 10 mm in diameter and height with near-net amorphous structure were synthesized at 150 °C with a sintering time of 90 min, resulting in densification as high as 98.2% with minimal crystallization. Sintering at extended durations above 90 min achieved higher densification and resulted in a significant amount of local and partial devitrification. Mechanical properties were characterized via compression and microhardness testing. Compression results show that increased sintering time led to better structural integrity and mechanical properties. Notably, SPS150_90 displayed ultimate compressive strength (220 MPa) that matches that of the cortical bone (205 MPa). Corrosion properties were characterized via potentiodynamic polarization with Phosphate Buffered Solution (PBS). The results suggest that the sintered samples have significantly better corrosion resistance compared to the crystalline form. Overall, SPS150_90 was observed to have a good balance between corrosion properties (10× better corrosion resistance to as-cast alloy) and mechanical properties.

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Mg-based bulk metallic glasses: A review of recent developments

Cited by 35 publications

References 112 publications

Combining Mg–Zn–Ca Bulk Metallic Glass with a Mesoporous Silica Nanocomposite for Bone Tissue Engineering

Combining Mg–Zn–Ca Bulk Metallic Glass with a Mesoporous Silica Nanocomposite for Bone Tissue Engineering

{Ca, Eu, Yb}23Cu7Mg4 as a Step towards the Structural Generalization of Rare Earth-Rich Intermetallics

Enhancing Mechanical and Biocorrosion Response of a MgZnCa Bulk Metallic Glass through Variation in Spark Plasma Sintering Time

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