Mg–Ca–Zn bio-degradable light alloys produced in a levitation induction melting furnace

Geantă, Victor; Voiculescu, Ionelia; Kelemen, Hajnal; Manu, Doina; Molnár, G.; Kelemen, Gyorgy

doi:10.3233/jae-209113

Cited by 6 publications

(10 citation statements)

References 17 publications

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“…Deepening the characterization of the texture of a MgCa implant depends largely on the behavior of the alloy, even when the texture is improved, the behavior of MgCa alloys will show tendencies towards brittleness.(128)(129). Various efforts have been made to improve the casting process and consequently the mechanical properties of MgCa alloys (48). However, no matter how much the process can be improved, it must be considered that the eutectic lamellar phases that originate will always be present in the incorporation of Ca to Mg, the homogenization due to the improvements in foundry offers to improve the biocompatibility( 130 In Fig.…”

Section: Discussionmentioning

confidence: 99%

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Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Becerra

Rodríguez

León

et al. 2021

Preprint

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Background The bio-fabrication of a porous scaffold from a selection procedure of elements taking into account the biological behavior, using Magnesium (Mg) alloyed with Calcium (Ca) and Zinc (Zn), it could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in osteosynthesis, contributing to osseointegration and contributing to infection control through the release of drugs, additionally, another possible attribute of this alloy would be to be used as a complementary treatment for osteosarcoma, this is due to the basification produced by oxidative degradation. (Attack on cancer cells)(1)(2)(3)(4).Methods The evaluation of cell viability of an alloy of Mg − 25 wt% Ca + 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considerations on the preparation of an alloy of Mg − 25 wt% Ca + 5 wt% Zn and its morphological characterization, will help to understand the applicability for the development of new surgical techniques and lead to a deeper investigation in the conception of alternative treatments. However, it is very important to bear in mind the mechanical effect of elements such as Ca and Zn, on the degradation of the alloy matrix, the best alternative to predict the biological - mechanical potential starts with the selection of the essential - nutritional elements (5)(6)(7) and its mechanical evaluation by micro-indentation due to the fragility of the matrix (8)(9).Results Therefore, the morphological evaluation of the specimens of Mg − 25 wt% Ca + 5 wt% Zn will show the crystallinity of the alloy; these results together generate a contribution regarding the design of biomedical alloys for use in treatments for various medical specialties.Conclusions The results indicated that cell viability is not affected, and there are no morphological changes in the cells.

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Section: Discussionmentioning

confidence: 99%

“…Kumar et al reported that the limitations of Mg smelting are characterized by a precarious distribution of elements causing segregation and porosity (66). Avoiding the contact of the elements to be melted with other surfaces is of vital importance to avoid contamination with traces and impurities (48).…”

Section: Methodsmentioning

confidence: 99%

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Becerra

Rodríguez

León

et al. 2021

Preprint

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“…Moreover, the Zn addition decreases the elastic modulus of HAP coatings, a positive result, which can reveal that the Zn based HAP coatings is proper for biomedical applications. The challenge is to obtain materials with the elastic modulus close to the value of human bones [1,5,8,9,18,32]. In Table 3, the H 3 /E 2 ratio is also calculated, which is related to the resistance to plastic deformation, a parameter sensitive to corrosion properties of the materials [50].…”

Section: Hardness Elastic Modulus and Roughnessmentioning

confidence: 99%

“…Currently, there is a wide variety of high entropy alloys that can be used in different fields, due to their special and specific properties, including industrial, aeronautical, military, medical applications and so on [7][8][9]. The high entropy alloys from the FeMoTaTiZr alloying system can be used for the manufacture of medical devices, human prosthesis, and implants.…”

Section: Introductionmentioning

confidence: 99%

Bio-Functionalization of a Novel Biocompatible High Entropy Alloy Used For Bone Implants

Mm¹,

Vlădescu²,

Geanta³

et al. 2021

Preprint

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In this paper, a novel biocompatible alloy defined as FeMoTaTiZr was obtained and functionalized by hydroxyapatite-based coatings (HAP) in order to increase their biocompatibility, bioactivity, and resistance to corrosion for to be used as bone implants. To obtain the surface with antibacterial properties, the HAP coatings were doped with small amount of Zn. The alloy was prepared using the VAR (Vacuum Arc Remelting) equipment, while the coatings by RF magnetron sputtering method. The EDS analysis confirmed the presence of Ca and P in the case of all developed coatings, having Ca/P or Ca/(P+Zn) ratio of about 1.70 and 1.66, respectively. The XRD and ATR-FTIR investigations confirmed the presence of calcium phosphate phases. The roughness of uncoated substrates increased after coating with HAP, and it was considerably increased by the Zn addition. The electrochemical tests showed that the un-doped HAP exhibited good corrosion behavior, while Zn doped HAP coatings have a high dissolution rate in fetal bovine serum, being more proper as a biodegradable material.

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“…In the smelting of non-ferrous alloys, oxidation should be avoided. It is advisable to melt in a reductive atmosphere using gases such as argon, SF6 and/or Flux; in addition, using a vacuum will reduce porosity and generate grain refining [6,[39][40][41]. The diffusioncontrolled oxidation process obeys the parabolic law [41,42].…”

Section: Introductionmentioning

confidence: 99%

Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold

Becerra

Torres–Castro

2021

Crystals

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This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in addition to possible applications in osteosynthesis, through contrib-uting to osseointegration and infection control through the release of drugs. Finally, another pos-sible attribute of this alloy could be its use as a complementary treatment for osteosarcoma; this is due to the basification produced by oxidative degradation (attack on cancer cells). The evaluation of cell viability of an alloy of Mg - 25 wt% Ca - 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considera-tions on the preparation of an alloy of Mg - 25 wt% Ca - 5 wt% Zn and its morphological charac-terization will help researchers understand its applicability for the development of new surgical techniques and lead to a deeper investigation of alternative treatments. However, it is very im-portant to bear in mind the mechanical effect of elements such as Ca and Zn on the degradation of the alloy matrix; the best alternative to predict the biological-mechanical potential starts with the selection of the essential-nutritional elements and their mechanical evaluation by mi-cro-indentation due to the fragility of the matrix. Therefore, the morphological evaluation of the specimens of Mg - 25 wt% Ca - 5 wt% Zn will show the crystallinity of the alloy; these results to-gether contribute to the design of biomedical alloys for use in treatments for various medical spe-cialties. The results indicated that cell viability is not affected, and there are no morphological changes in the cells.

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Mg–Ca–Zn bio-degradable light alloys produced in a levitation induction melting furnace

Cited by 6 publications

References 17 publications

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Bio-Functionalization of a Novel Biocompatible High Entropy Alloy Used For Bone Implants

Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold

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