Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity

Abstract

The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent postimplementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750-1200 °C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to Mg/Cu co-substituted hydroxyapatitebiocompatibility, mechanical properties and antimicrobial activity

Preparation and characterization of biocomposites based on chitosan and biomimetic hydroxyapatite derived from natural phosphate rocks

“…It is important to highlight that the apparition of β-TCMP phase and the increasing of its fraction with increasing of calcination temperature is the result of the limited incorporation of Mg in HA lattice. As reported by Veljovic et al [48],…”

“…This distortion perhaps is the result of β-TCMP precipitation [44]. Furthermore endothermic events were shown by the DSC curve, where a small peak at 884 °C and broad peak above 947 °C appeared, which re ect the dehydroxylation of HA, and phase transformation of crystalline phases respectively [48].…”

Calotropis Gigantea Fiber─A Biogenic Reinforcement Material for Europium Substituted Hydroxyapatite/Poly(3,4-propylenedioxythiophene) Matrix: A Novel Ternary Composite for Biomedical Applications

“…Inadequate studies have been attempted on the synthesis of HAP using snail shells as a calcium source. , Moreover, the substitution of Ca 2+ ions with various bioactive ions such as Mg 2+ , Zn 2+ , Mn 2+ , Sr 2+ , Ag 2+ , Ba 2+ Y 3+ , La 3+ , Sm 3+ , Ce 3+, Eu 3+ , etc., enhances the biological properties of HAP. The minerals substituted in HAP will enhance cell adhesion and proliferation of osteoblast cells, improve bioactivity, and provide excellent antimicrobial activity. − The trivalent cations are reported to exhibit improved biocompatibility and bioactive properties when compared to the divalent cations. Cell adhesion and proliferation were also found to be increased with the ions substituted in HAP .…”

Preparation and Characterization of Biocomposite Based on Chitosan and Biomimetic Hydroxyapatite Derived from Natural Phosphate Rocks

“…It is important to highlight that the apparition of β-TCMP phase and the increasing of its fraction with increasing of calcination temperature is the result of the limited incorporation of Mg in HA lattice. As reported by Veljovic et al [48], biological HA usually contains a wide variety of trace elements including Mg, indeed, the presence of the latter element in the structure of HA during the synthesis process causes little substitution of Ca 2+ , thus increasing the tension in the network, which promotes the formation of other phases. The lattice parameters of the heat-treated samples determined by Rietveld re nement of the XRD data are shown in Fig.…”