Mg-Zn-Ca Alloys for Hemostasis Clips for Vessel Ligation: In Vitro and In Vivo Studies of Their Degradation and Response

Chang, Y. Austin; Tseng, Chin Chung; Chao, Chih-Yeh; Ch, Chen; Lin, Sung‐Yen; Du, Je‐Kang

doi:10.3390/ma13133039

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…The Mg-Zn-Ca-Y clip degraded completely after eight months. Coated Mg-2.8Zn-0.8Ca clips exhibited good biocompatibility when applied on rabbit uterine tubes for five weeks (Figure 7(a)) [419,420]. Notably, a pure-Mg clip was recognized as an innovative medical device by CFDA in 2018 (https://www.cmde.org.cn/xwdt/ shpgzgg/cxyxgsh/20180308143746124.html).…”

Section: Surgical Instruments For Hemostasis and Anastomosismentioning

confidence: 99%

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Biodegradable Mg-based alloys: biological implications and restorative opportunities

Lin

Saijilafu

et al. 2022

International Materials Reviews

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Mg-based alloys as revolutionary implantable biomaterials have increasingly attracted considerable attention, owing to their biodegradability in vivo and beneficial effects on biological systems. The degradation process and products of Mg-based alloys have been reported to exhibit significant biological effects on host-tissue responses. However, these effects have not yet been fully understood. This review systemically summarizes and analyses the current understandings and recent research progress in this area. The primary focal points are the biological effects and related mechanisms associated with the degradation behaviour of Mg-based alloys. The biological impacts of the degradation products are elucidated and the arguable or controversial issues are also discussed, providing a pathway toward a greater understanding of the biological implications of Mg-based alloys. Furthermore, based on these biological implications, the restorative potential of Mg-based alloys for applications in tissue repair and regeneration is summarized. Finally, outlooks on biosafety evaluation and design strategies for Mg-based alloy implants are briefly discussed.

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Section: Surgical Instruments For Hemostasis and Anastomosismentioning

confidence: 99%

“…Biological effects of Mg-based alloys on soft-tissue healing processes remain to be determined [143,426], and are highly dependent on the alloy composition and degradation nature [143]. Moreover, the degradation behaviour should be optimized to match the requirements of soft tissue repair [419].…”

Section: Surgical Instruments For Hemostasis and Anastomosismentioning

confidence: 99%

Biodegradable Mg-based alloys: biological implications and restorative opportunities

Lin

Saijilafu

et al. 2022

International Materials Reviews

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“…The advantageous properties could be attained only if the reinforcements are distributed homogeneously and not clustered in the matrix. According to the literature available [ 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 ], limited research has been performed on CNT-reinforced MMCs due to difficulties in fabricating and dispersion of CNTs in the matrix. Most studies investigated the fabrication methods such as the casting process and powder metallurgy for developing Mg-based alloy [ 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 ,…”

Section: Summary and Future Road Mapsmentioning

confidence: 99%

Carbon Nanotubes (CNTs)-Reinforced Magnesium-Based Matrix Composites: A Comprehensive Review

et al. 2020

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In recent years considerable attention has been attracted to magnesium because of its light weight, high specific strength, and ease of recycling. Because of the growing demand for lightweight materials in aerospace, medical and automotive industries, magnesium-based metal matrix nanocomposites (MMNCs) reinforced with ceramic nanometer-sized particles, graphene nanoplatelets (GNPs) or carbon nanotubes (CNTs) were developed. CNTs have excellent material characteristics like low density, high tensile strength, high ratio of surface-to-volume, and high thermal conductivity that makes them attractive to use as reinforcements to fabricate high-performance, and high-strength metal-matrix composites (MMCs). Reinforcing magnesium (Mg) using small amounts of CNTs can improve the mechanical and physical properties in the fabricated lightweight and high-performance nanocomposite. Nevertheless, the incorporation of CNTs into a Mg-based matrix faces some challenges, and a uniform distribution is dependent on the parameters of the fabricating process. The characteristics of a CNTs reinforced composite are related to the uniform distribution, weight percent, and length of the CNTs, as well as the interfacial bonding and alignment between CNTs reinforcement and the Mg-based matrix. In this review article, the recent findings in the fabricating methods, characterization of the composite’s properties, and application of Mg-based composites reinforced with CNTs are studied. These include the strategies of fabricating CNT-reinforced Mg-based composites, mechanical responses, and corrosion behaviors. The present review aims to investigate and conclude the most relevant studies conducted in the field of Mg/CNTs composites. Strategies to conquer complicated challenges are suggested and potential fields of Mg/CNTs composites as upcoming structural material regarding functional requirements in aerospace, medical and automotive industries are particularly presented.

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“…Lui et al developed a histological evaluation on Mg-Zn and observed the formation of new trabeculae surrounded by osteoblasts and osteoclasts, consequently, they observed mature bone tissue and lamellar bone, as characteristics fundamental for the consolidation of bone regeneration(57)(58). Chang et al carried out a histological study in animals observing good tolerance of the organism to metal ions, showing from an early stage a biocompatible response (59). Sarkar et al report proliferation of osteocytes and mononuclear cells in the medullary cavity of a rabbit femur, indicating the beginning of an important healing process from Zn-doped MgP (60)(61).…”

Section: Introductionmentioning

confidence: 99%

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Becerra

Rodríguez

León

et al. 2021

Preprint

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Background The bio-fabrication of a porous scaffold from a selection procedure of elements taking into account the biological behavior, using Magnesium (Mg) alloyed with Calcium (Ca) and Zinc (Zn), it could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in osteosynthesis, contributing to osseointegration and contributing to infection control through the release of drugs, additionally, another possible attribute of this alloy would be to be used as a complementary treatment for osteosarcoma, this is due to the basification produced by oxidative degradation. (Attack on cancer cells)(1)(2)(3)(4).Methods The evaluation of cell viability of an alloy of Mg − 25 wt% Ca + 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considerations on the preparation of an alloy of Mg − 25 wt% Ca + 5 wt% Zn and its morphological characterization, will help to understand the applicability for the development of new surgical techniques and lead to a deeper investigation in the conception of alternative treatments. However, it is very important to bear in mind the mechanical effect of elements such as Ca and Zn, on the degradation of the alloy matrix, the best alternative to predict the biological - mechanical potential starts with the selection of the essential - nutritional elements (5)(6)(7) and its mechanical evaluation by micro-indentation due to the fragility of the matrix (8)(9).Results Therefore, the morphological evaluation of the specimens of Mg − 25 wt% Ca + 5 wt% Zn will show the crystallinity of the alloy; these results together generate a contribution regarding the design of biomedical alloys for use in treatments for various medical specialties.Conclusions The results indicated that cell viability is not affected, and there are no morphological changes in the cells.

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Mg-Zn-Ca Alloys for Hemostasis Clips for Vessel Ligation: In Vitro and In Vivo Studies of Their Degradation and Response

Cited by 13 publications

References 38 publications

Biodegradable Mg-based alloys: biological implications and restorative opportunities

Biodegradable Mg-based alloys: biological implications and restorative opportunities

Carbon Nanotubes (CNTs)-Reinforced Magnesium-Based Matrix Composites: A Comprehensive Review

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

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