Gravitational decoupled compact polytropic hybrid stars are here addressed in generalized Horndeski scalar-tensor gravity. Additional physical properties of hybrid stars are scrutinized and discussed in the gravitational decoupling setup. The asymptotic value of the mass function, the compactness, and the effective radius of gravitational decoupled hybrid stars are studied for both cases of a bosonic and a fermionic prevalent core. These quantities are presented and discussed as functions of Horndeski parameters, the decoupling parameter, the adiabatic index, and the polytropic constant. Important corrections to general relativity and generalized Horndeski scalar-tensor gravity, induced by the gravitational decoupling, comply with available observational data. Particular cases involving white dwarfs, boson stellar configurations, neutron stars, and Einstein–Klein–Gordon solutions, formulated in the gravitational decoupling context, are also scrutinized.