MGUS prevalence in an ethnically Chinese population in Hong Kong

Minter, Alex; Costello, Rene; Zingone, Adriana; Lee, Cheuk Kwong; Au, Wing Y.; Landgren, Ola

doi:10.1182/blood-2012-11-466011

Cited by 24 publications

(19 citation statements)

References 8 publications

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“…Our results showed that MGUS prevalence values in Korean men in their 40 (0.00%), 50 (1.63%), and >60 years of age (3.80%) were similar to MGUS values for Japanese males in their 40 (1.2%), 50 (2.7%), and >60 years of age (4.3%) and Chinese men 50–65 years (1.2%) [8, 9]. To date, the MGUS prevalence in Koreans has been determined only in elderly people >65 years [3].…”

Section: Discussionsupporting

confidence: 67%

Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males

Jeong

Lee

Chun

et al. 2014

BioMed Research International

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Background. We investigated the association between the reduction in the estimated glomerular filtration rate (eGFR) and the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in Korean males. Methods. We enrolled 723 healthy Korean males. Serum creatinine concentration, serum electrophoresis, serum immunofixation, and the serum free light chain assay were performed. We calculated delta eGFR per year (ΔeGFR/yr). The prevalence of MGUS was compared based on the ΔeGFR/yr and age group. Results. Thirteen (1.8%) of 723 participants exhibited the monoclonal band on serum immunofixation. Prevalence of MGUS by age group was 0.00% (0/172 for 40 years), 1.63% (6/367 for 60 years), and 3.80% (7/184 for >60 years). The median decrease in ΔeGFR/yr was 5.3%. The prevalence of MGUS in participants in their 50s with >5.3% decline in ΔeGFR/yr was significantly higher than those with <5.3% decrease in ΔeGFR/yr (3.16% versus 0.00%; P = 0.049). The prevalence of MGUS in participants in their 50s with >5.3% decrease in ΔeGFR/yr was similar to that of healthy males in their 60s. Conclusion. Using the rate of reduction in ΔeGFR/yr in healthy Korean males who had their serum creatinine level checked regularly may increase the MGUS detection rate in clinical practice.

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Section: Discussionsupporting

confidence: 67%

Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males

Jeong

Lee

Chun

et al. 2014

BioMed Research International

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“…Our results show that the overall prevalence of MGUS in the Yixing population 50 years of age or older was 0.44%, which is lower than the values of Thailand (2.3%) [2], Japan (2.4%) [3], and Olmsted County (3.2%) [6]. Our value was also lower than that of Hong Kong (0.8%) [4], despite having almost the same Chinese ethnicity, and this may be related to the different methods used. In our study, patients with a suspicious SPEP were subjected to immunofixation electrophoresis and FLC assays; however, patients with an abnormal FLC ratio and/or suspicious SPEP were subjected to immunofixation electrophoresis in the study of Hong Kong.…”

Section: Tablecontrasting

confidence: 52%

“…The prevalence of MGUS varies from 0.24 to 5.89 % in different countries and increases with patients' advancing age, which is influenced by race, age, sex, and so on [2,3,4,5,6,7]. Specifically, the overall prevalence of MGUS in Thailand is 2.3% [2], which is a bit higher than that in Japan (2.1%) [3 ]and much higher than the values in Hong Kong (0.8%) [4] and Nigeria (0.24%) [5]. Furthermore, the prevalence was shown to be 3.2% [6] in Olmsted County and 5.89% [7 ]in the Ghanaian population among people older than 50 years.…”

Section: Tablementioning

confidence: 99%

Prevalence of Monoclonal Gammopathy of Undetermined Significance in an Apparently Healthy Yixing Population in Mainland China

Wen²,

Tang³

et al. 2016

Acta Haematol

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“…Furthermore, we used established and standardized protein assays that allowed comparison with other population-based studies. 42,50 …”

Section: Discussionmentioning

confidence: 99%

Agent Orange Exposure and Monoclonal Gammopathy of Undetermined Significance

et al. 2015

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Importance Multiple myeloma has been classified as exhibiting “limited or suggestive evidence” of an association with exposure to herbicides in Vietnam Veterans. Occupational studies have shown that other pesticides (i.e., insecticides, herbicides, fungicides) are associated with excess risk of multiple myeloma (MM) and its precursor state, monoclonal gammopathy of undetermined significance (MGUS); however no studies have uncovered such an association in Vietnam Veterans. Objective To examine the relationship between MGUS and exposure to Agent Orange, including its contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in Vietnam Veterans. Design Our study is a prospective cohort study, testing for MGUS in serum specimens collected and stored in 2002 by the Air Force Health Study (AFHS). The relevant exposure data collected by the AFHS was also used. We tested all specimens in 2013 without knowledge of the exposure status. The AFHS included former US Air Force personnel who participated in Operation Ranch Hand (Ranch Hand Veterans) and other US Air Force personnel who had similar duties in Southeast Asia during the same time period but were not involved in herbicide spray missions (comparison Veterans). Setting Agent Orange was used by the US Air Force personnel who conducted aerial spray missions of herbicides (Operation Ranch Hand) in Vietnam from 1962–1971. Participants We included 479 Ranch Hand Veterans and 479 comparison Veterans who participated in the 2002 follow-up examination of AFHS. Exposure Agent Orange and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, a contaminant of Agent Orange). Serum TCDD levels were measured in 1987, 1992, 1997, and 2002. Main Outcomes and Measures Risk of MGUS measured by prevalence, odds ratios (OR), and 95% confidence intervals (CI). Results The prevalence of MGUS in Ranch Hand Veterans (7.1%) was higher than in comparison Veterans (3.1%) (adjusted OR=2.37, 95% CI, 1.27–4.44; P=0.007). The cohort status was significantly (P=0.0001) associated with TCDD levels: 47% of Ranch Hand Veterans had serum TCDD levels >10.92 ppt compared to 2.5% of comparison Veterans. Conclusions and Relevance Ranch Hand Veterans have a significantly increased risk of MGUS, supporting an association between Agent Orange exposure and multiple myeloma.

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MGUS prevalence in an ethnically Chinese population in Hong Kong

Cited by 24 publications

References 8 publications

Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males

Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males

Prevalence of Monoclonal Gammopathy of Undetermined Significance in an Apparently Healthy Yixing Population in Mainland China

Agent Orange Exposure and Monoclonal Gammopathy of Undetermined Significance

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