MHC Class I Genes in Nonhuman Primates

Cadavid, Luis F.; Watkins, David I.

doi:10.1007/978-3-642-59086-3_13

Cited by 6 publications

(10 citation statements)

References 52 publications

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“…1), is a solitary LTR in the alpha-block and it, too, appears to have been a relatively recent insertion in primate history occurring during the evolution of hominoids (Jurka and Smit, personal communication). Homologues of HLA-A sequence, however, have reportedly been found in chimpanzees, gorillas, orangutans, gibbons, and Old World monkeys but not in New World monkeys (Cadavid and Watkins 1997). The identification of gorilla HLA-A alleles similar to HLA-H was interpreted to represent an interlocus segmental exchange between the two loci (Watkins et al 1991), although the results may also be interpreted as allelic inheritance from a preduplication sequence or the existence of different alleles within the ancestor of HLA-A and HLA-H genomic segments.…”

Section: A Model For the Coevolution Of Retroelements And Perb11 And mentioning

confidence: 99%

Coevolution of PERB11 (MIC) and HLA Class I Genes with HERV-16 and Retroelements by Extended Genomic Duplication

et al. 1999

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The recent availability of genomic sequence information for the class I region of the MHC has provided an opportunity to examine the genomic organization of HLA class I (HLAcI) and PERB11/MIC genes with a view to explaining their evolution from the perspective of extended genomic duplications rather than by simple gene duplications and/or gene conversion events. Analysis of genomic sequence from two regions of the MHC (the alpha- and beta-blocks) revealed that at least 6 PERB11 and 14 HLAcI genes, pseudogenes, and gene fragments are contained within extended duplicated segments. Each segment was searched for the presence of shared (paralogous) retroelements by RepeatMasker in order to use them as markers of evolution, genetic rearrangements, and evidence of segmental duplications. Shared Alu elements and other retroelements allowed the duplicated segments to be classified into five distinct groups (A to E) that could be further distilled down to an ancient preduplication segment containing a HLA and PERB11 gene, an endogenous retrovirus (HERV-16), and distinctive retroelements. The breakpoints within and between the different HLAcI segments were found mainly within the PERB11 and HLA genes, HERV-16, and other retroelements, suggesting that the latter have played a major role in duplication and indel events leading to the present organization of PERB11 and HLAcI genes. On the basis of the features contained within the segments, a coevolutionary model premised on tandem duplication of single and multipartite genomic segments is proposed. The model is used to explain the origins and genomic organization of retroelements, HERV-16, DNA transposons, PERB11, and HLAcI genes as distinct segmental combinations within the alpha- and beta-blocks of the human MHC.

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Section: A Model For the Coevolution Of Retroelements And Perb11 And mentioning

confidence: 99%

Coevolution of PERB11 (MIC) and HLA Class I Genes with HERV-16 and Retroelements by Extended Genomic Duplication

et al. 1999

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“…Orthologues of the human MHC class I loci HLA-A, -B, -E, -F, and -G are remarkably well preserved throughout the infraorder Catarrhini (Old World primates, apes, and humans; refs. [3][4][5][6][7][8]. In addition to the evolutionary stability of the loci, sharing of allelic lineages has been observed between different species of primates (9)(10)(11).…”

mentioning

confidence: 99%

Evolutionary instability of the major histocompatibility complex class I loci in New World primates

Cadavid

Shufflebotham

Ruiz

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

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Homologues of the human major histocompatibility complex (MHC) HLA-A, -B, -E, -F, and -G loci are present in all the Catarrhini (Old World primates, apes, and humans), and some of their allelic lineages have survived several speciation events. Analysis of 26 MHC class I cDNAs from seven different genera of New World primates revealed that the Callitrichinae (tamarins and marmosets) are an exception to these rules of MHC stability. In gene trees of primate MHC class I genes, sequences from the Callitrichinae cluster in a genus-specific fashion, whereas in the other genera of New World primates, as in the Catarrhini, they cluster in a transgeneric way. The genus-specific clustering of the Callitrichinae cDNAs indicates that there is no orthology between MHC class I loci in genera of this phyletic group. Additionally, the Callitrichinae genera exhibit limited variability of their MHC class I genes, in contrast to the high variability displayed by all other primates. Each Callitrichinae genus, therefore, expresses its own set of MHC class I genes, suggesting that an unusually high rate of turnover of loci occurs in this subfamily. The limited variability of MHC class I genes in the Callitrichinae is likely the result of the recent origin of these loci.

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“…The bonobo exon 2 is related to HLA-B27, but not exons 3-8 [41]. E, F, and G gene products complexes with beta-2-microglobulin.…”

Section: Histocompatibility Antigensmentioning

confidence: 98%

“…Reactive arthritis, is more common in humans with the histocompatibility gene, HLA-B27 [4,5••,23]. While HLA-B27 and other human major histocompatibility complex (MHC) Class I loci are apparently not present in nonhuman primates, analogous components, referred to as "orthologues" are present in Old World Catarrhini (monkeys) and apes [41,53,54,55], but apparently not among other mammals [56,57]. Equivalents of HLA-A, B, and C have been detected in chimpanzees, bonobos, gorillas, orangutans, gibbons, and rhesus macaques [58•].…”

Section: Histocompatibility Antigensmentioning

confidence: 99%

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Primate spondyloarthropathy

Rothschild

2005

Curr Rheumatol Rep

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Spondyloarthropathy is a common occurrence in Old World primates, with only limited presence in New World monkeys. Clearly distinguished from rheumatoid arthritis, this erosive arthritis afflicts 20% of great apes, baboons, and rhesus macaques and had been increasing in frequency. Habitat-dependent infectious agent diarrhea-induced reactive arthritis is implicated on a background of genetic predisposition. A gorilla-derived therapeutic preventative approach has possible application in human clinical medicine.

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MHC Class I Genes in Nonhuman Primates

Cited by 6 publications

References 52 publications

Coevolution of PERB11 (MIC) and HLA Class I Genes with HERV-16 and Retroelements by Extended Genomic Duplication

Coevolution of PERB11 (MIC) and HLA Class I Genes with HERV-16 and Retroelements by Extended Genomic Duplication

Evolutionary instability of the major histocompatibility complex class I loci in New World primates

Primate spondyloarthropathy

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