This paper examined the contribution of MHD, thermal radiation, thermophoresis and Soret–Dufour mechanism on unsteady motion of Casson non‐Newtonian fluid. The flow model which resulted in partial differential equations (PDES) was transformed into a dimensionless form of PDES using suitable quantities. The contributions of controlling flow parameters were graphically presented for velocity, temperature, and concentration. The quantities of engineering interest were calculated for flow parameters and presented using table. A considerable value of Soret parameter was noticed to elevate the skin friction and Sherwood number. Impact of the magnetic parameter has great impact on the motion of Casson fluid by lowering its motion. This is because as the value of magnetic parameter increases the Lorentz force added more strength and hereby slow down the motion of an electrically conducting fluids. The present outcomes were examined with previously published work and was in conformity with each other.