Riga plate is known to create a crossing electric and magnetic field to generate a wall-parallel Lorentz force. The significance of Casson nanofluid flow past a Riga plate is observed in the sphere of engineering, such as polymer extrusion, food manufacturing, plastic films, oil reserves and geothermal manufacturing. Researchers are interested in this model because of its potential use in biological rheological models. As Casson nanofluid flows are of great interest, this study aims to investigate the three-dimensional magnetohydrodynamics (MHD) flow with heat and mass transport of Casson nanofluid over a flat Riga plate. As a novelty, this study also includes the effectiveness of wall velocity slip, activation energy, nonlinear radiation, and temperature and space-dependent heat source/sink. Suitable similarity transformations have been employed to generate the dimensionless ordinary differential equations (ODEs) from the partial differential equations (PDEs) regulating the fluid flow problem. The transformed nonlinear boundary value problem is then solved numerically using the in-built routine “bvp4c” in MATLAB. The visual demonstrations are provided for the effects of various significant physical factors on the flow, heat and mass distributions. On the other hand, wall shear stress and rates of heat and mass transport at the surface are measured and displayed numerically in tabular form. The findings indicate that the fluid velocity in both directions slows as the velocity slip parameter increases. However, the velocity profile is escalated with the boost of modified Hartmann number. An increase in heat source parameters leads to decrease the heat transmission rate at the wall. The higher values of the radiation parameter result in a better wall heat transmission rate. Further, the rate of mass transport drops when the activation energy parameter is hiked.