The present research paper highlights the effect of multiple slips and inclined magnetic fields on chemically reacting Casson-Williamson with Buongiorno modeled nanofluid flow past a permeable stretching surface. Considered physical factors associated with heat transfer are viscous dissipation, Joule's heating, radiation, and double diffusion effects. The ordinary differential equations (ODEs) are formulated from governing system of highly nonlinear Partial differential equations (PDEs) by a suitable implementation of similarity invariants. The numerical results are obtained by programming the resulting equations in MATLAB software via Runge-Kutta (R-K) fourth-order technique along with the shooting scheme. The graphical illustration provides the behavior of velocity, temperature, and concentration on different non-dimensional parameters. It is worth to notice the slip parameters are greatly analogs with various physical properties of the flow field. The effect of a magnetic parameter ([Formula: see text]), Casson parameter ([Formula: see text]), Williamson parameter ([Formula: see text]), velocity slip effect ([Formula: see text]), and the inclination ([Formula: see text]) on axial velocity are shown graphically. The outstanding agreement is observed after a comparison of numerical outcomes with previously published work. The applied magnetic field and thermal radiation insert more energy into the system which improves the thermal boundary layer.