“…They should also be easy and straightforward to understand and use [ 1 , 4 , 13 , 19 , 40 , 42 , 117 , 135 , 141 , 150 , 193 , 194 , 203 , 208 , 217 , 250 , 252 , 265 , 266 , 273 ], as well as have the ability to be personalized according to patient needs and preferences [ 4 , 13 , 62 , 117 , 208 , 216 , 217 , 220 , 246 ]. Finally, a key property and enabler of the reimbursement of digital therapeutics is their interaction with the target population: they should be co-designed and coimplemented with patients and health professionals to maximize the likelihood of their uptake by the relevant stakeholders, with the recognition of the fact that engagement might differ across population groups in different countries [ 4 , 13 , 19 , 40 , 47 , 56 , 57 , 89 , 129 , 166 , 174 , 189 , 190 , 200 , 214 , 215 , 220 , 230 , 250 ].…”