MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C

Liu, Mengping; Liu, Xiaojun; Zhen, Wei; Hua, Rui; Huang, Yuzhi; Xiang, Hao; Yuan, Zuyi; Zhou, Juan

doi:10.1136/jim-2021-002314

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…In our study, MHR showed significant differences between CAD and non-CAD groups, and it remained a risk factor for CAD based on multifactor regression analysis. Liu et al also demonstrated that a higher MHR is a risk factor for severe stenosis, and even though patients with chest pain have achieved LDL-C < 1.8 mmol/l, MHR maintained their predictive abilities and remained associated with the occurrence and severity of CAD [22].…”

Section: Discussionmentioning

confidence: 96%

“…Liu et al . also demonstrated that a higher MHR is a risk factor for severe stenosis, and even though patients with chest pain have achieved LDL-C < 1.8 mmol/l, MHR maintained their predictive abilities and remained associated with the occurrence and severity of CAD [ 22 ]. Our study also examined the diagnostic value of MHR: When the cutoff value of MHR was set to 0.47, the prediction ability for CAD was the highest.…”

Section: Discussionmentioning

confidence: 99%

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Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease

Zhao

Lian

Liu

et al. 2023

Coronary Artery Disease

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Objective We aimed to investigate the relationship between coronary artery disease (CAD) and systemic inflammation indices and lipid metabolism-related factors and subsequently, discuss the clinical application of these factors in CAD. Methods We enrolled 284 consecutive inpatients with suspected CAD and divided them into a CAD group and a non-CAD group according to coronary angiography results. Serum levels of angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding protein 4 (FABP4), and tumor necrosis factor-α (TNF-α) levels were assessed using the ELISA and the systemic inflammation indices were calculated. Multivariate logistic regression was used to assess the risk factors of CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values. Results The neutrophil-to-high density lipoprotein cholesterol ratio (5.04 vs. 3.47), neutrophil-to-lymphocyte ratio (3.25 vs. 2.45), monocyte-to-high density lipoprotein cholesterol ratio (MHR) (0.46 vs. 0.36), monocyte-to-lymphocyte ratio (0.31 vs. 0.26), systemic immune-inflammation index (SII) (696.00 vs. 544.82), serum TNF-α (398.15 ng/l vs. 350.65 ng/l), FABP4 (1644.00 ng/l vs. 1553.00 ng/l), ANGPTL3 (57.60 ng/ml vs. 52.85 ng/ml), and ANGPTL4 (37.35 ng/ml vs. 35.20 ng/ml) values showed a significant difference between the CAD and non-CAD groups (P < 0.05). After adjusting for confounding factors, the following values were obtained: ANGPTL3 > 67.53 ng/ml [odds ratio (OR) = 8.108, 95% confidence interval (CI) (1.022–65.620)]; ANGPTL4 > 29.95 ng/ml [OR = 5.599, 95% CI (1.809–17.334)]; MHR > 0.47 [OR = 4.872, 95% CI (1.715–13.835)]; SII > 589.12 [OR = 5.131, 95% CI (1.995–13.200)]. These factors were found to be independently associated with CAD (P < 0.05). Diabetes combined with MHR > 0.47, SII > 589.12, TNF-α >285.60 ng/l, ANGPTL3 > 67.53 ng/ml, and ANGPTL4 > 29.95 ng/l had the highest diagnostic value for CAD [area under the curve: 0.921, 95% CI, (0.881–0.960), Sensitivity: 88.9%, Specificity: 82.2%, P < 0.001]. Conclusion MHR > 0.47, SII > 589.12, TNF-α >285.60 ng/l, ANGPTL3 > 67.53 ng/ml, and ANGPTL4 > 29.95 ng/l were identified as independent CAD risk factors and have valuable clinical implications in the diagnosis and treatment of CAD.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease

Zhao

Lian

Liu

et al. 2023

Coronary Artery Disease

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“…Lamichhane P et al [ 44 ] have demonstrated that NHR can be used for risk stratification and for predicting short-term and long-term prognoses in clinical cardiovascular diseases. Additionally, Liu M et al [ 45 ] identified an independent correlation between NHR and coronary heart disease and severe stenosis in patients presenting with chest pain. NHR also showed comparable predictive value for severe coronary stenosis.…”

Section: Discussionmentioning

confidence: 99%

The relationship between NLR, LDL-C/HDL-C, NHR and coronary artery disease

Yuan,

Li,

et al. 2024

PLoS ONE

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Objective Chronic inflammation and dyslipidemia are key risk factors for atherosclerotic cardiovascular diseases. We retrospectively explored the association between the neutrophil to lymphocyte ratio (NLR), the ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C), and the neutrophil to HDL-C ratio (NHR), and the severity of coronary lesions in patients with acute coronary syndrome (ACS). Method In June 2023, we selected 1210 patients who were diagnosed with ACS based on chest pain from January 2017 to December 2022. Of these, 1100 patients with abnormal coronary angiography were categorized into the experimental group, and 110 patients with normal coronary angiography were classified as the control group. We collected routine blood tests, lipid profiles, and coronary angiography results at admission (before coronary angiography). Patients were then stratified into a control group (Gensini score = 0) and an experimental group (Gensini score = 0) based on the Gensini score. The experimental group was further divided into a low score group (Gensini score < 69) and a high score group (Gensini score ≥ 69). Result 1. Statistically significant differences were observed between the control and experimental groups in terms of gender, age, body mass index (BMI), hypertension, diabetes, smoking history, and counts of neutrophils (NEU), lymphocytes (LYM), monocytes (MON), eosinophils (EOS), red cell distribution width (RDW), total cholesterol (TC), HDL-C, LDL-C, NLR, LDL-C/HDL-C, and NHR (P<0.05). Furthermore, differences in BMI, hypertension, diabetes, smoking history, NEU, LYM, MON, TC, triglyceride (TG), HDL-C, LDL-C, NLR, LDL-C/HDL-C, and NHR were significant between the low and high score groups (P<0.05). 2. NEU, LYM, MON, TC, HDL-C, LDL-C, NLR, LDL-C/HDL-C, and NHR showed significant correlations with the Gensini score (r>0.2, P<0.05), with NLR and LDL-C/HDL-C showing the strongest correlations (r = 0.822, P = 0.000). 3. The Receiver Operating Characteristic (ROC) curve indicated that the combination of NLR and LDL-C/HDL-C had superior sensitivity and specificity in predicting the severity of coronary lesions, with a significant difference (P<0.05). The sensitivity was 87.1%, the specificity was 90.9%, and the cut-off point was 2.04. 4. A predictive model was developed based on the ratio of NLR and LDL-C/HDL-C to the Gensini score. The final model score was calculated as 6.803 + 7.029NLR + 13.079LDL-C/HDL-C (R2 = 0.708). Conclusion Compared to NLR, LDL-C/HDL-C, and NHR, the combined NLR and LDL-C/HDL-C ratio is a more accurate marker for assessing the severity of coronary artery disease in ACS patients. Its convenience and effectiveness make it a promising tool for early assessment, timely risk stratification, and appropriate clinical intervention, ultimately improving clinical outcomes for ACS patients.

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“…Recent data on MHR in CVD in male patients are limited, and they describe a higher MHR in men with CCS [9,10]. Furthermore, this marker was shown to be an independent predictor of CCS diagnosis [11,12] and progression [9,13,14]. Higher MHR was also observed in patients with acute coronary syndrome (ACS) [15][16][17], stent embolus in patients with ACS treated with percutaneous coronary intervention [18], and microvascular angina [19].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Serum 25-Hydroxyvitamin D Concentration, Monocyte-to-HDL Ratio and Acute Coronary Syndrome in Men with Chronic Coronary Syndrome—An Observational Study

Dziedzic,

Gąsior,

Tuzimek

et al. 2023

Nutrients

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Cardiovascular disease (CVD) continues to be the leading cause of death in European men. Atherosclerosis and its clinical consequence, chronic coronary syndrome (CCS), comprise two main elements: dysfunction of lipoprotein metabolism and an important inflammatory component that contributes to the development of complications, including acute coronary syndrome (ACS). Measures of both components are combined in a composite marker called monocyte-to-HDL ratio (MHR). Vitamin D was previously described to influence inflammation processes, and its deficiency influences CVD risk factors. This research describes the differences in MHR and total serum 25-hydroxyvitamin D (25(OH)D) concentration between male patients with different diagnoses of CCS and the correlation between 25(OH)D and MHR in this group. Significant differences were observed between ACS and CCS patients in 25(OH)D and MHR—the highest HDL and serum 25(OH)D concentrations were observed in patients with CCS, whereas the highest value of MHR was observed in patients with STEMI. A significant correlation was observed between 25(OH)D, HDL, and MHR. Due to the significant but small nominal difference in MHR values between groups of patients diagnosed with ACS and CCS, and the possible influence of age and hyperlipidemia status on the differences in vitamin D levels in these groups, this subject requires further well-designed research. The suggested bidirectional relationship between MHR and 25(OH)D and the role of MHR as a predictor of vitamin D status in the body also needs to be verified.

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MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C

Cited by 5 publications

References 42 publications

Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease

Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease

The relationship between NLR, LDL-C/HDL-C, NHR and coronary artery disease

Correlation between Serum 25-Hydroxyvitamin D Concentration, Monocyte-to-HDL Ratio and Acute Coronary Syndrome in Men with Chronic Coronary Syndrome—An Observational Study

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