2015
DOI: 10.1021/acs.jproteome.5b00525
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MI-PVT: A Tool for Visualizing the Chromosome-Centric Human Proteome

Abstract: We have developed the web-based Michigan Proteome Visualization Tool (MI-PVT) to visualize and compare protein expression and isoform-level function across human chromosomes and tissues (http://guanlab.ccmb.med.umich.edu/mipvt). As proof of principle, we have populated the tool with Human Proteome Map (HPM) data. We were able to observe many biologically interesting features. From the vantage point of our chromosome 17 team, for example, we found more than 300 proteins from chromosome 17 expressed in each of t… Show more

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Cited by 4 publications
(5 citation statements)
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“…miR-21 or 21), and it will automatically provide all the corresponding entries from our database. 3.4.3 User interactive and downloadable graphs All graphs are provided in the user-interactive mode for better visualization and customization, as developed previously for proteomics data (Panwar et al, 2015). A user can select or hide a particular miRNA from the graph by using an option at the bottom of the column graph.…”
Section: Mirna-based Searchmentioning
confidence: 99%
“…miR-21 or 21), and it will automatically provide all the corresponding entries from our database. 3.4.3 User interactive and downloadable graphs All graphs are provided in the user-interactive mode for better visualization and customization, as developed previously for proteomics data (Panwar et al, 2015). A user can select or hide a particular miRNA from the graph by using an option at the bottom of the column graph.…”
Section: Mirna-based Searchmentioning
confidence: 99%
“…The GTEx portal is useful to explore relationships between genetic variation and gene/isoform expression in various human tissues . The present IsoFunc Web server is also linked with our recently developed in-house tools Hisonet and MI-PVT . The MI-PVT is a tool for visualizing the chromosome-centric human proteome, while Hisonet displays predicted isoform-level functional networks.…”
Section: Resultsmentioning
confidence: 99%
“…44 The present IsoFunc Web server is also linked with our recently developed in-house tools Hisonet 45−47 and MI-PVT. 48 The MI-PVT is a tool for visualizing the chromosomecentric human proteome, while Hisonet displays predicted isoform-level functional networks. Functionally connected PCSVs in Hisonet may be different from IsoFunc because Hisonet is based on the RefSeq database, while IsoFunc utilizes Ensembl and Hisonet used additional information such as pseudoamino acid composition, protein-docking, and protein domains with coexpression values to generate the functional networks.…”
Section: Isofunc Webservermentioning
confidence: 99%
“…This tool can be used to identify samples with high amount of transcript for MPs of category PE2 [33]. The Michigan Proteome Visualization Tool (MI-PVT), developed by the Chromosome 17 teams of the US, is a web-based tool that displays by chromosome or by protein family [34]. The iterative threading assembly refinement (I-TASSER) and COFACTOR algorithms, which are well-established tools in structural biology for predicting protein folding and protein functions, were applied to the list of 572 PE5 uncertain/dubious predicted proteins to evaluate their prospects for conformational folding and potential functions [35].…”
Section: Progressmentioning
confidence: 99%