mi<scp>RNA</scp>‐15a, mi<scp>RNA</scp>‐16, mi<scp>RNA</scp>‐126, mi<scp>RNA</scp>‐146a, and mi<scp>RNA</scp>‐223 expressions in autologous hematopoietic stem cell transplantation and their impact on engraftment

Nowicki, Mateusz; Szemraj, Janusz; Wierzbowska, Agnieszka; Misiewicz, Małgorzata; Małachowski, Roman; Pluta, Agnieszka; Grzybowska–Izydorczyk, Olga; Robak, Tadeusz; Szmigielska-Kapłon, Anna

doi:10.1111/ejh.13036

Cited by 13 publications

(7 citation statements)

References 57 publications

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“…Biologic factors and processes influencing the behavior of hematopoietic cells during mobilization and transplantation have still not been fully discovered and understood; however, it is known that in the complex milieu of components participating in HSC maintenance, survival, proliferation, and differentiation [ 57 , 58 ], different elements such as adhesive molecules, growth factors, cytokines, proteases, miRNAs, and sirtuins are involved [ 59 , 60 , 61 ]. Among these factors, sirtuins may play an important role in the mobilization of HSCs through their deacetylating activity, which regulates many important processes related to the fate of HSCs, their metabolism, stress response, differentiation, aging, and apoptosis [ 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

Anoxia Rapidly Induces Changes in Expression of a Large and Diverse Set of Genes in Endothelial Cells

Antonelli

Scarpa

Bruzzone³

et al. 2023

IJMS

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Sinusoidal endothelial cells are the predominant vascular surface of the bone marrow and constitute the functional hematopoietic niche where hematopoietic stem and progenitor cells receive cues for self-renewal, survival, and differentiation. In the bone marrow hematopoietic niche, the oxygen tension is usually very low, and this condition affects stem and progenitor cell proliferation and differentiation and other important functions of this region. Here, we have investigated in vitro the response of endothelial cells to a marked decrease in O2 partial pressure to understand how the basal gene expression of some relevant biological factors (i.e., chemokines and interleukins) that are fundamental for the intercellular communication could change in anoxic conditions. Interestingly, mRNA levels of CXCL3, CXCL5, and IL-34 genes are upregulated after anoxia exposure but become downmodulated by sirtuin 6 (SIRT6) overexpression. Indeed, the expression levels of some other genes (such as Leukemia Inhibitory Factor (LIF)) that were not significantly affected by 8 h anoxia exposure become upregulated in the presence of SIRT6. Therefore, SIRT6 mediates also the endothelial cellular response through the modulation of selected genes in an extreme hypoxic condition.

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Section: Resultsmentioning

confidence: 99%

Anoxia Rapidly Induces Changes in Expression of a Large and Diverse Set of Genes in Endothelial Cells

Antonelli

Scarpa

Bruzzone³

et al. 2023

IJMS

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“…Patients with higher serum levels of miR-214 had extended overall survival upon bisphosphonate-based therapy ( 68 ). In patients with autologous stem-cell transplantation, the lower level of miR-15a on day 0 was associated with the shorter time to engraftment, and miR-20a decreased at complete remission ( 69 , 70 ). These results demonstrate that the expression patterns of circulating microRNAs are valuable markers for predicting treatment response.…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNAs as Auxiliary Diagnostic Biomarkers for Multiple Myeloma: A Systematic Review, Meta-Analysis, and Recommendations

et al. 2021

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Multiple myeloma (MM) is a hematologic malignancy characterized by aberrant expansion of monoclonal plasma cells with high mortality and severe complications due to the lack of early diagnosis and timely treatment. Circulating miRNAs have shown potential in the diagnosis of MM with inconsistent results, which remains to be fully assessed. Here we updated a meta-analysis with relative studies and essays published in English before Jan 31, 2021. After steps of screening, 32 studies from 11 articles that included a total of 627 MM patients and 314 healthy controls were collected. All data were analyzed by REVMAN 5.3 and Stata MP 16, and the quality of included literatures was estimated by Diagnostic Accuracy Study 2 (QUADAS-2). The pooled area under the curve (AUC) shown in summary receiver operating characteristic (SROC) analyses of circulating miRNAs was 0.87 (95%CI, 0.81–0.89), and the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were 0.79, 0.86, 5, 0.27, 22, respectively. Meta-regression and subgroup analysis exhibited that “miRNA cluster”, patient “detailed stage or Ig isotype” accounted for a considerable proportion of heterogeneity, revealing the importance of study design and patient inclusion in diagnostic trials; thus standardized recommendations were proposed for further studies. In addition, the performance of the circulating miRNAs included in MM prognosis and treatment response prediction was summarized, indicating that they could serve as valuable biomarkers, which would expand their clinical application greatly.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=234297, PROSPERO, identifier (CRD42021234297).

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“…We evaluated the kinetics of circulating miRNA-15a, miRNA-16, miRNA-126 and miRNA-146a as well as miRNA-223 in the group of patients with lymphoproliferative malignancies before autologous HSCT and early after transplantation [93]. We observed a…”

Section: High-level Expression Of Granulocyte-macrophage Progenitors mentioning

confidence: 98%

“…Expression of this miRNA is induced by the NF-κB protein complex, which plays a significant role in inflammatory response [90]. MiRNA-146a regulates mobilization of HSC as well as their homing after bone marrow transplantation [90][91][92][93]. Previous research has shown that under the influence of G-CSF, expression of CXCR4 chemokine receptor mRNA and protein in AML cells was decreased while the level of miRNA-146a was increased [94].…”

Section: Mirna-146amentioning

confidence: 99%

Selected factors influencing angiogenesis and hematopoietic niche

Nowicki

Stelmach²,

Szmigielska-Kapłon³

2018

Acta Haematologica Polonica

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Angiogenesis is the vital, multistage process in which new blood vessels are created by sprouting from pre-existing vessels. It takes part in carcinogenesis and contributes to progression, metastases, and dissemination of neoplastic disease. In the bone marrow, angiogenesis influences the hematopoietic stem cells (HSC) proliferation, differentiation, and maintenance of normal hematopoiesis under both physiological and stress conditions. The bone marrow niche contains different types of cells, including macrophages, osteoblasts, mesenchymal stem cells, endothelial progenitors, and endothelial cells. All of these interact and form a unique microenvironment necessary for the appropriate function, and preservation of HSC in the quiescent state, and take a major part in the process of mobilization to peripheral blood and homing after transplantation. Cytokines active in the hematopoietic niche as well as miRNAs regulating hemato- poiesis, and angiogenesis have a significant influence on processes occurring in the bone marrow. The aim of this review was to present selected proteins, and molecules associated with angiogenesis as well as bone marrow niche processes: VEGF, ANGPT1, ANGPT2, MMP-9, SDF-1, miRNA-15a, miRNA-16, miRNA-126, miRNA-146a, and miRNA-223.

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miRNA‐15a, miRNA‐16, miRNA‐126, miRNA‐146a, and miRNA‐223 expressions in autologous hematopoietic stem cell transplantation and their impact on engraftment

Abstract: In conclusion, all investigated microRNAs changed significantly in the course of transplantation. Our results suggest that the miRNAs may participate in hematopoietic recovery in the early post-transplant period and influence engraftment efficiency after HSCT.

Cited by 13 publications

References 57 publications

Anoxia Rapidly Induces Changes in Expression of a Large and Diverse Set of Genes in Endothelial Cells

Anoxia Rapidly Induces Changes in Expression of a Large and Diverse Set of Genes in Endothelial Cells

Circulating miRNAs as Auxiliary Diagnostic Biomarkers for Multiple Myeloma: A Systematic Review, Meta-Analysis, and Recommendations

Selected factors influencing angiogenesis and hematopoietic niche

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