MIA-dependent angiogenesis and lymphangiogenesis are closely associated with progression, nodal metastasis and poor prognosis in tongue squamous cell carcinoma

Sasahira, Tomonori; Kirita, Tadaaki; Kurihara, Miyako; Yamamoto, Kazuhiko; Bhawal, Ujjal K.; Bosserhoff, Anja‐Katrin; Kuniyasu, Hiroki

doi:10.1016/j.ejca.2010.04.027

Cited by 46 publications

(85 citation statements)

References 40 publications

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“…New blood and lymphatic vessels in tumors can grow by sprouting from pre-existing vessels or by recruitment of rare, circulating, bone marrow-derived endothelial progenitor cells (6,7). The molecular basis of lymphangiogenesis is only partially understood due to an overlap between markers of endothelial cells (ECs) and lymphatic endothelial cells (LECs), the lack of specific lymphatic molecular markers, and the unavailability of good experimental models.…”

Section: Introductionmentioning

confidence: 99%

IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma

et al. 2015

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Abstract. Lymphangiogenesis is not only involved in the processes of embryonic development, tissue repair and chronic inflammation, but also in tumor lymphatic metastasis. Metastatic tumor cells spreading through lymphatic vessels occur in non-small cell lung carcinoma (NSCLC), with regional lymph node metastasis often being the most important prognostic factor for carcinoma patients. Recent research has identified a range of lymphangiogenic growth factors that could conceivably play a great role in promoting tumor lymphangiogenesis and lymphatic metastasis. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: vascular endothelial growth factor-C (VEGF-C) and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor-3 (VEGFR-3). Targeting VEGF pathway strategy sometimes failed to decrease tumor metastasis in vivo experiments and clinical trials. It is unclear whether the tumor cells induced the lymphangiogenesis process, while VEGF pathway could not completely illustrate the mechanism of tumor cell lymphatic metastasis. To explore the novel tumor lymphangiogenesis targets, we screened 181 candidate genes between high lymphatic vascular density (LVD) and low LVD in lung adenocarcinomas using Human Genome U133 Plus 2.0 Microarray. Insulin-like growth factor binding protein 7 (IGFBP7) was proven to be associated with metastatic clinicopathological features and high LVD. Furthermore, by assessing the capability of lymphatic endothelial cell forming lymphatic vessel-like structures in vitro, it appears to enhance lymphangiogenesis.

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Section: Introductionmentioning

confidence: 99%

IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma

et al. 2015

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“…Finally, we analyzed the effect of siRNA HuD treatment on the expression of several target genes (VEGF-A, c-myc, N-myc, and Notch3) by [10,11,12]. We also investigated the effect of the activation of other VEGF family members (VEGF-C/D) and MMP-2/9 since HuD expression was significantly associated with nodal metastasis and mode of invasion in the present immunohistochemistry examination, and higher expression of these factors in HSC3 cells was shown in previous reports [1,6,20]. Although expression of c-myc, N-myc, Notch3 and VEGF-C was largely unaffected, we identified that enhancement of VEGF-A/D, and MMP-2/9 were regulated by HuD in HSC3 cells (fig.…”

Section: Resultsmentioning

confidence: 73%

“…Immunoreactivity of HuD was classified according to Allred's score (AS) [19] and we divided the immunoreactivity into 4 grades by AS: grade 0, AS 0; grade 1, AS approximately 2-4; grade 2, AS 5 or 6; grade 3, AS 7 or 8. Cases with grade 2 and 3 were regarded as immunologically positive [1,6]. …”

Section: Methodsmentioning

confidence: 99%

“…We previously reported that the high-mobility group box-1 receptor for advanced glycation end products and melanoma inhibitory activity signal plays a pivotal role in tumor progression and nodal metastasis, and is implicated in a worse prognosis in OSCC [1,3,5,6]. However, it remains unclear whether or not it is a specific diagnostic and therapeutic marker of OSCC, and further research is needed.…”

Section: Introductionmentioning

confidence: 99%

“…Over 80% of early-stage OSCCs can be cured by treatment, whereas more than 70% of advanced-stage OSCCs cannot. Overall, 5-year survival rates of OSCC have not significantly improved during the past 3 decades and the 5-year survival rate is less than 50% [5,6]. Therefore, early detection is important and an understanding of the detailed molecular mechanism of OSCC is urgently required.…”

Section: Introductionmentioning

confidence: 99%

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HuD Promotes Progression of Oral Squamous Cell Carcinoma

Sasahira

Kurihara²,

Yamamoto³

et al. 2014

Pathobiology

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Head and neck cancer, including oral squamous cell carcinoma (OSCC), ranks as the sixth most common malignancy worldwide. Overall 5-year survival rates of OSCC have not significantly improved during the past 3 decades and the 5-year survival rate is less than 50%. Several invasion grading systems have been employed in OSCC, however, their utility is still controversial. HuD belongs to the Hu protein family and acts as an RNA-binding protein involved in mRNA stability and translational regulation. Although HuD has a pivotal role for neuronal differentiation, the functional role of HuD in OSCCs is still unclear. In this study, we examined HuD expression in 82 OSCC cases. Expression of HuD was observed in 36.6% of OSCCs and significantly associated with histological differentiation, nodal metastasis and mode of invasion. HuD expression in high-metastatic HSC3 cells was higher than in low-metastatic HSC4 cells, and inhibition of invasion ability and activation of caspase-3 were shown by HuD siRNA-treated HSC3 cells. Furthermore, we clarified that HuD regulates expression of vascular endothelial growth factor (VEGF)-A, VEGF-D, matrix metallopeptidase (MMP)-2 and MMP-9. These results suggest that HuD is a useful diagnostic and therapeutic target in OSCCs.

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Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta‐analysis of literature

Liu

Liang

et al. 2013

Head & Neck

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MIA-dependent angiogenesis and lymphangiogenesis are closely associated with progression, nodal metastasis and poor prognosis in tongue squamous cell carcinoma

Cited by 46 publications

References 40 publications

IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma

IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma

HuD Promotes Progression of Oral Squamous Cell Carcinoma

Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta‐analysis of literature

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