Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis

Parra-Martínez, Cecilio; Selma‐Royo, Marta; Callejón‐Leblic, Belén; Collado, María Carmen; Abril, Nieves; García‐Barrera, Tamara

doi:10.1016/j.jhazmat.2022.129443

Cited by 16 publications

(9 citation statements)

References 52 publications

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“…Recent evidence suggests that the role of selenium and selenoproteins in brain functioning extends beyond protection against oxidative stress, and may involve protective effects or functional interactions with dopaminergic, cholinergic, and GABAergic pathways, as well as the effect of selenoprotein P on specific post-synaptic receptors [73]. There is also evidence that selenium can alter the functioning of the gut-brain axis [74] and may be involved in the regulation of the stress response through interaction between glucocorticoids and selenoproteins [41]. This evidence has led to an interest in the use of selenium or its compounds in the management of common mental disorders, namely, depression and anxiety disorders.…”

Section: Discussionmentioning

confidence: 99%

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar

2022

Future Pharmacology

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Anxiety disorders are among the most common mental disorders worldwide and often respond incompletely to existing treatments. Selenium, a micronutrient that is a component of several biologically active selenoproteins, is also involved in several aspects of brain functioning and may exert antidepressant and anxiolytic effects through multiple pathways. The current paper is a scoping review of translational, observational, and interventional evidence on the potential role of selenium and its compounds in the management of anxiety and related disorders. Evidence from animal models suggests that this approach may be promising. Though evidence from observational studies in humans is inconsistent and affected by several confounding factors, the available evidence from randomized controlled trials suggests that selenium supplementation may be beneficial in the management of certain anxiety-related conditions, such as anxiety in medically ill patients, prevention of anxiety following exposure to traumatic stress, and obsessive-compulsive disorder. This paper provides a critical evaluation of the existing evidence base, including unanswered questions that could serve as the focus of further research, and outlines the potential benefits and risks associated with the use of selenium in anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar

2022

Future Pharmacology

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“…Recent evidence suggests that the role of selenium and selenoproteins in brain functioning extends beyond protection against oxidative stress, and may involve protective effects or functional interactions with dopaminergic, cholinergic, and GABAergic pathways, as well as the effect of selenoprotein P on specific post-synaptic receptors [72]. There is also evidence that selenium can alter the functioning of the gut-brain axis [73] and may be involved in the regulation of the stress response through interaction between glucocorticoids and selenoproteins [41]. This evidence has led to an interest in the use of selenium or its compounds in the management of common mental disorders, namely, depression and anxiety disorders.…”

Section: Discussionmentioning

confidence: 99%

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar¹

2022

Preprint

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Anxiety disorders are among the most common mental disorders worldwide, and often respond incompletely to existing treatments. Selenium, a micronutrient that is a component of several biologically active selenoproteins, is also involved in several aspects of brain functioning, and may exert antidepressant and anxiolytic effects through multiple pathways. The current paper is a scoping review of translational, observational and interventional evidence on the potential role of selenium and its compounds in the management of anxiety and related disorders. Evidence from animal models suggests that this approach may be promising. Though evidence from observational studies in humans is inconsistent and affected by several confounding factors, the available evidence from randomized controlled trials suggests that selenium supplementation may be beneficial in the management of certain anxiety-related conditions, such as anxiety in medically ill patients, prevention of anxiety following exposure to traumatic stress, and obsessive-compulsive disorder. This paper provides a critical evaluation of the existing evidence base, including unanswered questions that could serve as the focus of further research, and outlines the potential benefits and risks associated with the use of selenium in anxiety disorders.

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“…Untargeted metabolomic analysis after Se supplementation have been performed using mice models [47,73,[85][86][87][88][89][90][91][92][93][94][95][96][97][98], pigs [99][100][101][102], broilers [103], cells [104], rats [105][106][107], gazelle [108], zebra fish [109], humans [110], donkeys [111], salmon [112], and catfish [113]. These studies reported a wide range of altered metabolites after Se supplementation focused on liver [73, 91, 94-96, 100-102, 105, 112] and plasma/serum metabolism [73,92,96,101,105,108,110], but also in muscle [99,103], kidneys [73,93], testes [73], lungs [73,90], spleen [96], blood…”

Section: Metabolomic Studies Related To the Impact Of Dietary Seleniu...mentioning

confidence: 99%

Omics insights into the responses to dietary selenium

Arias‐Borrego,

Callejón‐Leblic,

Collado

et al. 2023

Proteomics

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Selenium is a well‐known health‐relevant element related with cancer chemoprevention, neuroprotective roles, beneficial in diabetes, and in several infectious diseases, among others. It is naturally present in some foods, but deficiency in people led to the production of nutraceuticals, supplements, and functional food enriched in this element. There is a U‐shaped link between selenium levels and health and a narrow range between toxic and essential levels, and thus, supplementation should be performed carefully. Omics methodologies have become valuable approaches to delve into the responses of dietary selenium in mammals that allowed a deeper knowledge about the metabolism of this element as well as its biological role. In this review, we discuss omics approaches from the workflows to their applications that has been previously used to deep insight into the metabolism of dietary selenium. There is a special focus on selenoproteins, metabolomics responses in blood and tissues (e.g., brain, reproductive organs, etc.) as well as the impact on gut microbiota and its metabolites profile. Thus, we mainly reviewed heteroatom‐tagged proteomics, metallomics, metabolomics, and metataxonomics, usually combined with transcriptomics, genomics, and other molecular methods.

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Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis

Cited by 16 publications

References 52 publications

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Omics insights into the responses to dietary selenium

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