Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

Cycling, stressed-out and nervous: cellular functions of c-Abl

“…The mouse c-abl gene was one of the first genes targeted by homologous recombination, which generated a true null allele 12 and one encoding a truncated Abl protein with intact kinase activity 13 . Interestingly, both knockout alleles resulted in the same phenotype: abl -/-mice are born runted, have shortened survival and exhibit abnormal eyes, frequent rectal prolapse and defective spermatogenesis 14 .…”

JAK-STAT signaling activated by Abl oncogenes

“…The phenotype of the c-Abl de®cient mice has suggested that both the kinase domain and the carboxyl terminal region of c-Abl are required for early B cell development (Schwartzberg et al, 1991;Tybulewicz et al, 1991). It is also noteworthy that the IL-7/IL-7R, JAK 1, or JAK 3 de®cient mice have a similar phenotype in early B cell development.…”

“…These studies, in addition to genetic manipulation of abl genes (Schwartzberg et al, 1991;Tybulewicz et al, 1991), have suggested that Abl proteins may be involved in multiple cellular processes. The majority of Abl-interacting proteins or substrates identi®ed to date are proteins involved in the transduction of signals leading to gene transcription and cellular proliferation or survival (reviewed in Zou and Calame, 1999).…”

Functional role for the c-Abl tyrosine kinase in meiosis I

“…The c-Abl nonreceptor tyrosine kinase is expressed in diverse tissues, including germ line cells of the testes (Meijer et al, 1987;Oppi et al, 1987;Ponzetto and Wolgemuth, 1985;Schwartzberg et al, 1991). c-Abl is a nuclear and cytoplasmic protein which contains Src homology SH2 and SH3 domains, a tyrosine kinase domain, and actin and DNA-binding domains (Lewis et al, 1996;Wang, 1993).…”