1992
DOI: 10.1016/0042-6822(92)90526-u
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Mice immunized with a subviral particle containing the japanese encephalitis virus prM/M and E proteins are protected from lethal JEV infection

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Cited by 168 publications
(114 citation statements)
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“…Our data of protein expression by transfected cells is in agreement with previous works that demonstrate the prM gene is necessary for the correct expression of the E protein genes [9,[25][26][27]. The prM protein consists of approximately 165 amino acids and is accepted that it might function as a chaperone for folding and assembly of the E protein [28].…”
Section: Discussionsupporting
confidence: 91%
“…Our data of protein expression by transfected cells is in agreement with previous works that demonstrate the prM gene is necessary for the correct expression of the E protein genes [9,[25][26][27]. The prM protein consists of approximately 165 amino acids and is accepted that it might function as a chaperone for folding and assembly of the E protein [28].…”
Section: Discussionsupporting
confidence: 91%
“…A 2-kb genomic region, from the internal signal peptide at the carboxyl terminus of C to the transmembrane domain at the carboxyl terminus of the E gene, is essential for expressing authentic proteins. These authentic prM and E proteins are able to self-assemble into virus-like particles in cells infected by either recombinant vaccinia virus or alphavirus vector or in cells transformed by recombinant plasmid DNA (4,19,22,48;Hunt and Chang,unpublished data).…”
Section: Discussionmentioning
confidence: 99%
“…JEV-specific humoral (30) and cellular (31,32) immune responses have been suggested to be responsible for protective immunity against JEV infection. Among the various structural and nonstructural proteins of JEV, the E protein appears to play the most important role in inducing protective immunity (24).…”
Section: Figurementioning
confidence: 99%