Mice (Mus musculus) reared with rat aunts: The role of rat-mouse contact in mediating behavioural and physiological changes in the mouse

Rosenberg, Kenneth M.; Denenberg, Victor H.; Zarrow, M. X.

doi:10.1016/0003-3472(70)90082-5

Cited by 29 publications

(19 citation statements)

References 12 publications

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“…showing that the group with the greatest (p Ͻ .01), amount of maternal stimulation in infancy had the lowest adrenal response to novelty stress (Rosenberg, Denenberg, & Zarrow, 1970).…”

Section: Cross-fostering Of Micementioning

confidence: 98%

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Commentary: Is maternal stimulation the mediator of the handling effect in infancy?

Denenberg

1999

Dev. Psychobiol.

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“…showing that the group with the greatest (p Ͻ .01), amount of maternal stimulation in infancy had the lowest adrenal response to novelty stress (Rosenberg, Denenberg, & Zarrow, 1970).…”

Section: Cross-fostering Of Micementioning

confidence: 98%

“…In addition, we correlated the summed maternal rating of each of the thelectomized aunts against the mean corticosterone litter value of their mouse pups (Rosenberg et al, 1970). Within the postpartum group, The correlation was not r ϭ Ϫ.61, n ϭ 24; p Ͻ .01. significant within the control aunt group.…”

Section: Cross-fostering Of Micementioning

confidence: 99%

Commentary: Is maternal stimulation the mediator of the handling effect in infancy?

Denenberg

1999

Dev. Psychobiol.

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“…Importantly, the emotional and neuroendocrine stress resistance observed in briefly separated rodents can be replicated in unmanipulated offspring that naturally receive high levels of maternal care during development (9). That increased maternal care is sufficient to produce stress resistance in rodents is corroborated by evidence that the amount of maternal stimulation received by pups during development is negatively correlated with later stress-induced HPAaxis activation (9,10).…”

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confidence: 92%

Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates

Parker

Buckmaster

Sundlass

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

185

152

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The stress inoculation hypothesis presupposes that brief intermittent stress exposure early in life induces the development of subsequent stress resistance in human and nonhuman primates. Rodent studies, however, suggest a role for maternal care rather than stress exposure per se (i.e., the maternal mediation hypothesis). To investigate these two hypotheses, we examined maternal care and the development of stress resistance after exposure to brief intermittent infant stress (IS), mother-infant stress (MIS), or no stress (NS) protocols administered to 30 monkeys between postnatal weeks 17 and 27. Unlike rodents, the IS condition did not permanently increase primate maternal care, nor did measures of total maternal care predict subsequent offspring hypothalamicpituitary-adrenal-axis responsivity. Although MIS infants received less maternal care than IS and NS infants, both IS and MIS monkeys developed subsequent stress resistance. These findings indicate that rearing differences in the development of stress resistance are more closely related to differences in prior stress exposure than to differences in maternal care. A second experiment confirmed this conclusion in a different cohort of 25 monkeys exposed as infants to high foraging-demand (HFD) or low foraging-demand (LFD) conditions. HFD infants exhibited intermittent elevations in cortisol levels and received less maternal care than LFD infants. In keeping with a key prediction of the stress inoculation hypothesis, HFD males responded to stress in adulthood with diminished hypothalamic-pituitary-adrenal-axis activation compared with LFD males. Results from both experiments demonstrate that stress inoculation, rather than high levels of maternal care, promotes the development of primate stress resistance.hypothalamic-pituitary-adrenal axis ͉ monkey ͉ maternal care ͉ resilience

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“…Previous experiments have found that mice reared by rat mothers, or by mouse mothers in the company of adult nonlactating female rats ("aunts"), are markedly less aggressive, are less active in the open-field, prefer a rat over a mouse in a 2-choice social preference test, and have a lesser adrenal cortical response to a novel stimulus at the time of weaning as compared to mouse-reared mice (Denenberg, Hudgens, .& Zarrow, 1964, 1966Denerlberg, Rosenberg, Paschke, Hess, Zarrow, & Levine, 1968;Denenberg, Rosenberg, Paschke, & Zarrow, 1969;Hudgens, Denenberg, & Zarrow, 1967, 1968Paschke, Denenberg, & Zarrow, 197 1;Rosenberg, Denenberg, & Zarrow, 1970). In the report by Paschke et al 2 strains of mice were employed, C57BL/10J…”

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confidence: 98%

Mice reared with rats: Effects of prenatal and postnatal maternal environments upon hybrid offspring of C57BL/10J and Swiss Albino mice

Denenberg

Paschke

Zarrow

1973

Developmental Psychobiology

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The hybrid offspring of reciprocal crosses between C57BL/ 1OJ and Swiss Albino mice were fostered at birth to Swiss Albino mouse mothers or to Purdue-Wistar rat mothers.Measures were taken of incidence of survival, body weight, open-field performance, passive avoidance learning, and fighting. As compared to mice reared by mouse mothers after birth, mice reared by rat mothers (a) had a lower incidence of survival at weaning; (b) weighed more; (c) were less active in the open field, defecated less in the field, and had a greater latency to initiate movement in the field; and (d) had poorer passive learning scores. The findings indicate that the postnatal maternal environment has pervasive effects upon a number of behavioral and morphological characters, but reveal a minimal effect of the prenatal environment. Moreover, they indicate that the absence of differences in fighting scores among the 4 groups may be caused by dominant genes.Parental influences may be imposed upon offspring through a number of routes. A major pathway is the transmission of information via the gametes at the time of conception or by means of extranuclear (cytoplasmic) inheritance.

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Mice (Mus musculus) reared with rat aunts: The role of rat-mouse contact in mediating behavioural and physiological changes in the mouse

Cited by 29 publications

References 12 publications

Commentary: Is maternal stimulation the mediator of the handling effect in infancy?

Commentary: Is maternal stimulation the mediator of the handling effect in infancy?

Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates

Mice reared with rats: Effects of prenatal and postnatal maternal environments upon hybrid offspring of C57BL/10J and Swiss Albino mice

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