Mice Regulate Dietary Amino Acid Balance and Energy Intake by Selecting between Complementary Protein Sources

Zaman, Kamrul; Mun, Hee-chang; Solon-Biet, Samantha M; Senior, Alistair M; Raubenheimer, David; Simpson, Stephen J; Conigrave, Arthur D

doi:10.1016/j.tjnut.2024.04.007

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…It is thus still unclear what the core expression responses to any eAA dietary deprivation are, and to which extent specific AA deprivations lead to unique gene expression changes in the animal. Behaviorally, deficiencies in dietary proteins or eAAs lead to a preference for protein-rich foods [25][26][27][28][29][30] . Remarkably, the removal of any of the ten eAA can be sufficient to induce a potent protein or AA appetite, as shown in Drosophila melanogaster 3 .…”

Section: Introductionmentioning

confidence: 99%

Lack of Single Amino Acids Transcriptionally Remodels Sensory Systems to Enhance the Intake of Protein and Microbiota

Ezra-Nevo,

Henriques,

Münch

et al. 2024

Preprint

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Adequate intake of dietary essential amino acids (eAAs) is vital for protein synthesis and metabolism. Any single eAA deprivation is sufficient to increase protein intake in Drosophila melanogaster. How such nutritional -needs- are transformed into behavioral -wants- remains poorly understood. We derived transcriptomes from the heads of flies deprived of individual eAAs to identify mechanisms by which this is achieved. We found that, while specific eAA deprivations have unique effects on gene expression, a large set of changes are shared across deprivations. We show that Or92a upregulation upon eAA deprivation increases the exploitation of yeast, the main protein source of flies. Furthermore, Ir76a upregulation was crucial for feeding on Lactobacillus, a gut bacterium that ameliorates the fitness of eAA-deprived flies. Our work uncovers common and unique transcriptional changes induced by individual eAA deprivations in an animal and reveals novel mechanisms underlying the organisms behavioral and physiological response to eAA challenges.

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Section: Introductionmentioning

confidence: 99%

Lack of Single Amino Acids Transcriptionally Remodels Sensory Systems to Enhance the Intake of Protein and Microbiota

Ezra-Nevo,

Henriques,

Münch

et al. 2024

Preprint

View full text Add to dashboard Cite

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Macronutrient interactions and models of obesity: Insights from nutritional geometry

Wali,

Ni,

Raubenheimer

et al. 2024

BioEssays

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The global obesity epidemic results from a complex interplay of genetic and environmental factors, with diet being a prominent modifiable element driving weight gain and adiposity. Although excess intake of energetic macronutrients is implicated in causing obesity, ongoing debate centers on whether sugar or fat or both are driving the rising obesity rates. This has led to competing models of obesity such as the “Carbohydrate Insulin Model”, the “Energy Balance Model”, and the “Fructose Survival Hypothesis”. Conflicting evidence from studies designed to focus on individual energetic macronutrients or energy rather than macronutrient mixtures underlies this disagreement. Recent research in humans and animals employing the nutritional geometry framework (NGF) emphasizes the importance of considering interactions among dietary components. Protein interacts with carbohydrates, fats, and dietary energy density to influence both calorie intake (“protein leverage”) and, directly and indirectly, metabolic physiology and adiposity. Consideration of these interactions can help to reconcile different models of obesity, and potentially cast new light on obesity interventions.

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FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

Khan,

Kim,

Ross

et al. 2025

Molecular Metabolism

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Mice Regulate Dietary Amino Acid Balance and Energy Intake by Selecting between Complementary Protein Sources

Cited by 4 publications

References 46 publications

Lack of Single Amino Acids Transcriptionally Remodels Sensory Systems to Enhance the Intake of Protein and Microbiota

Lack of Single Amino Acids Transcriptionally Remodels Sensory Systems to Enhance the Intake of Protein and Microbiota

Macronutrient interactions and models of obesity: Insights from nutritional geometry

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

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