2013
DOI: 10.3177/jnsv.59.454
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Mice That Are Fed a High-Fat Diet Display Increased Hepcidin Expression in Adipose Tissue

Abstract: Since the discovery that hepcidin is expressed in the adipose tissue of obese subjects, attention has been increasingly focused on alterations in iron homeostasis that are associated with adiposity. We examined the production of hepcidin, the expression of hepcidin-related genes and the iron content of the adipose tissue in obesity using Swiss mice fed a high-fat diet (HFD). The mice were maintained on a control diet or HFD for 12 or 24 wk, and body weight, adiposity and glucose homeostasis were evaluated. The… Show more

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Cited by 33 publications
(31 citation statements)
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“…Macrophages RNA were isolated, cDNA was synthesize, and the expression of the Tnf, IL10, Nos2, and Mrc1 (formerly CD206) was analyzed using real-time PCR as described 9 (see Supplementary Material for primers information). All reactions were performed in duplicate, and the average Ct value was used to assess gene expression.…”
Section: Blood and Tissue Collectionmentioning
confidence: 99%
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“…Macrophages RNA were isolated, cDNA was synthesize, and the expression of the Tnf, IL10, Nos2, and Mrc1 (formerly CD206) was analyzed using real-time PCR as described 9 (see Supplementary Material for primers information). All reactions were performed in duplicate, and the average Ct value was used to assess gene expression.…”
Section: Blood and Tissue Collectionmentioning
confidence: 99%
“…21 Macrophage isolation from adipose tissue, M1/M2 markers, and Prussian blue reaction Stromal vascular fraction (SVF) was obtained from epididymal adipose tissue after collagenase digestion as described before. 9 Macrophages (CD11b þ cells) were obtained from the SVF by sorting using magnetic-selected cell (Miltenyi Biotec, Germany).…”
Section: Blood and Tissue Collectionmentioning
confidence: 99%
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