Micellar assembly of a photo- and temperature-responsive amphiphilic block copolymer for controlled release

Yang, Fang; Cao, Zhuo; Wang, Guojie

doi:10.1039/c5py01435b

Cited by 57 publications

(39 citation statements)

References 73 publications

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“…prepared a micellar nanoparticle with a photo‐sensitive hydrophobic PNBM core and a temperature‐sensitive hydrophilic poly( N ‐isopropylacrylamide) (PNIPAM) shell, which self‐assembled from a well‐defined block copolymer. This self‐assembled micellar nanoparticle could be photo‐disrupted with light and shrunk at higher temperature, achieving the controlled release of encapsulated hydrophobic guest molecules from it under stimulation with light or temperature change . More sophisticated systems have also been reported by that is, Wang and coworkers who prepared a quadruple stimuli–responsive block copolymer nanocarrier that sensitive to pH, temperature, light, and reductant agent.…”

Section: Introductionmentioning

confidence: 99%

Preparation of quadruple responsive polymeric micelles combining temperature‐, pH‐, redox‐, and UV‐responsive behaviors and its application in controlled release system

Dong

Huo

et al. 2018

J of Applied Polymer Sci

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A novel series of quadruple responsive copolymers, poly(ethylene glycol)‐ss‐[poly(dimethylaminoethyl methacrylate)‐co‐poly(2‐nitrobenzyl methacrylate)] [PEG‐ss‐(PDMAEMA‐co‐PNBM)], were synthesized via atom transfer radical polymerization mediated by home‐made PEG‐based macro‐initiator labeled with disulfides. The obtained copolymers could self‐assemble in aqueous solution forming micelles with the disulfide bridge linking the hydrophilic coronas (PEG) and the hydrophobic cores (PDMAEMA‐co‐PNBM). Investigation on the resulted micelles indicated that the micelles could respond to various stimuli, that is, temperature, pH, the presence of dithiothreitol (DTT), and UV irradiation. Moreover, the responsive behavior of the micelles depends on the type of stimuli, that is, temperature change causes size change of the micelles, while UV irradiation leads to dissolution of the self‐assembled structures. Such stimulus‐dependent responsive behavior could be applied in smart materials that deal with multi‐tasks or in the construction of complex logic gate. The potential application of the multi‐responsive micelles in cargo release system was also evaluated using Nile Red (NR) as model molecule. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46675.

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Section: Introductionmentioning

confidence: 99%

Preparation of quadruple responsive polymeric micelles combining temperature‐, pH‐, redox‐, and UV‐responsive behaviors and its application in controlled release system

Dong

Huo

et al. 2018

J of Applied Polymer Sci

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“…The selection of monomers depends on their intended applications. Amphiphilic block copolymers have attracted significant attraction due to their self-assembly in selective solvents to form vesicles or micelles based on the solubility of their hydrophilic and hydrophobic segments [4,5]. Among them, stimuliresponsive polymers have been in the focus of intensive research in the last decade.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of amphiphilic block copolymers containing ferrocene–boronic acid and their micellization, redox-responsive properties and glucose sensing

Saleem

Wang

et al. 2017

Colloid Polym Sci

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Amphiphilic block copolymer PMAEFc-b-PMVAPBA was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The hydrophobic and hydrophilic blocks of copolymers self-assembled into spherical micelles in aqueous solution. The redox behaviour of ferrocene was studied by using water-soluble (NH 4 ) 2 Ce(NO 3 ) 6 and NaHSO 3 as the oxidizing agent and reducing agent, respectively. The change in polarity and swelling of micelles increased the hydrodynamic diameter due to the oxidation of ferrocene, while glucose binding with boronic acid hydroxyls leads to unimers or smaller aggregates. TEM and DLS were used to investigate the redox-controlled behaviour of micelles. This redox-responsive behaviour would provide a prerequisite for detection/binding of biological analytes study and redox-controlled release of drug.

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“…The cumulative releases of DOX from CCLM, SCLM, and SCCLM reached 43.9%, 61.5%, and 50.8%, respectively, when the temperature of the release media was 37 °C and other conditions remained unchanged. The DOX loaded into inner‐layer crosslinked micelles was squeezed out of micelles since the shell layer shrunk at 37 °C . In this case, the cumulative release of the drugs was about half of the loaded drugs, and the amount of DOX released from SCLM was higher than from the other two.…”

Section: Resultsmentioning

confidence: 97%

Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for controlled release

Zhang

Liu

et al. 2018

J of Applied Polymer Sci

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Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for drug delivery and release are designed. The well‐defined tetrablock copolymer poly(polyethylene glycol methacrylate)–poly[2‐(dimethylamino) ethyl methacrylate]–poly(N‐isopropylacrylamide)–poly(methylacrylic acid) (PPEGMA‐PDMAEMA‐PNIPAM‐PMAA) is synthesized via atom transfer radical polymerization, click chemistry, and esterolysis reaction. The tetrablock copolymer self‐assembles into noncrosslinked micelles in acidic aqueous solution. The core‐crosslinked micelles, shell‐crosslinked micelles, and shell–core dilayer‐crosslinked micelles are prepared via quaternization reaction or carbodiimide chemistry reaction. The crosslinked micelles are used as drug carriers to load doxorubicin (DOX), and the drug encapsulation efficiency with 20% feed ratio reached 59.2%, 73.1%, and 86.1%, respectively. The cumulative release rate of DOX is accelerated by single or combined stimulations. The MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay verifies that the inner‐layer crosslinked micelles show excellent cytocompatibility, and DOX‐loaded micelles exhibit significantly higher inhibition for HepG2 cell proliferation. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46714.

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Micellar assembly of a photo- and temperature-responsive amphiphilic block copolymer for controlled release

Abstract: Block copolymeric micellar nanoparticles in response to light and temperature change have been constructed for the controlled release of encapsulated molecules under stimulation with light and temperature change.

Cited by 57 publications

References 73 publications

Preparation of quadruple responsive polymeric micelles combining temperature‐, pH‐, redox‐, and UV‐responsive behaviors and its application in controlled release system

Preparation of quadruple responsive polymeric micelles combining temperature‐, pH‐, redox‐, and UV‐responsive behaviors and its application in controlled release system

Synthesis of amphiphilic block copolymers containing ferrocene–boronic acid and their micellization, redox-responsive properties and glucose sensing

Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for controlled release

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