Micellar catalysis in reactions of some β-lactam antibiotics with<b><i>p</i></b>-dimethylaminobenzaldehyde

Khalil, Rabah A.; Al-Khayat, R. Z.

doi:10.1080/00319100601084993

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…More *Corresponding author. E-mail: rakhalil64@yahoo.com recently, we have extended our investigations of the above reaction through using bromhexine drug [2,3] and three ȕ-lactams antibiotics [4] instead of sulfonamide. The colored solutions of these molecules do not show the above observed phenomenon of sulfanilamide.…”

Section: Introductionmentioning

confidence: 99%

Application of a Schiff base derived from sulfanilamide as an acid-base indicator

Khalil

Jalil

Abd-Alrazzak

2009

JICS

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The present paper firstly announces the possibility of using a Schiff base as an acid-base indicator. This surprising phenomenon can be considered as an interest due to the fact that Schiff bases are usually unstable in solutions and definitely undergo hydrolysis. It was found that such a specific observation depends merely upon the chemical structure and type of the substitute of amine that reacts with aldehyde to give the Schiff base. The latter reagent 4[(4-dimethylamino-benzylidene)-amino]-benzene sulfonamide was synthesized from the condensation of sulfanilamide with p-dimethylaminobenzaldehyde. The reagent solution shows a reproducible change in its color due to the addition of acid and base. A UV-Vis spectroscopic characterization and acid-base equilibrium study of the reagent for its possible use as an indicator were investigated. The results show that the reagent is an amphoteric which possesses four ionization constants K a1 , K a2 , K b1 and K b2 of weak dibasic and diacidic properties. The value of pK a2 (9.80) is parallel to the observed transition interval pH 9.5 (yellow) and pH 10.5 (colorless), which is considered to be the indicator exponents pK i . It was concluded that the benzyl sulfonamide group plays a key role in the stability of the reagent towards hydrolysis and also for indicator characteristics through breaking the conjugation.

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Section: Introductionmentioning

confidence: 99%

Application of a Schiff base derived from sulfanilamide as an acid-base indicator

Khalil

Jalil

Abd-Alrazzak

2009

JICS

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“…We have been reported that the employment of Equation (16) through multiple linear regression is the method of choice for determining binding constants. [3] This due to the fact that the later developed method does not has weak points in contrast to the previous methods. For example, the graphical treatment of the previous method contains the independent variable C in both x and y axis.…”

Section: Resultsmentioning

confidence: 88%

“…In our previous studies [3,4] we have employed the following statistical equation which was also derived from Equation (2) 1…”

Section: Resultsmentioning

confidence: 99%

“…As in previous research [3] k w can be neglected with respect to other term in Equation (1) since the rate decreases from a maxima as the anionic surfactant concentration increases and also k 0 m K A K B C >> k w . Therefore, Equation (1) can be written as…”

Section: First Multiple Linear Regression Equationmentioning

confidence: 93%

“…[3] The developed equation was applied for reactions of some b-lactams antibiotics with p-dimethylaminobenzaldehyde (DAB) in presence of sodium dodecyl sulphate (SDS) micelles. [3] It was proved to be the developed equation is more reliable and convenient for determining these parameters. The latter equation was also applied successfully to the condensation reaction of bromhexine with DAB in presence of SDS at different temperatures.…”

Section: Introductionmentioning

confidence: 99%

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Statistical and Mathematical Investigations for Determining the Binding Constants of Micelle with Reactants Molecules from Kinetic Data

Khalil

2009

Journal of Dispersion Science and Technology

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Binding constants between reactants molecules with micelles are considered to be important parameters particularly in micellar catalysis area. Recently, we developed a statistical method based on multiple linear regression for determining those parameters from kinetic data (Phys. Chem. Liq. 2008, 46, 34-46). In the present work, we derived further two statistical equations from the same original equation using also multiple linear regression method. A substantial difference has been found between the results of those equations and with that of the recently published one. This strongly indicates that the statistical procedures are not valid for such a purpose, that is, the available statistical and graphical methods in the literature are also not suitable for such treatment. A mathematical procedure using iterative method for evaluating the binding constants is introduced. An equation for such treatment has also been derived from the same original equation, and a computer program for this purpose has been written. Application of the developed method to the kinetic data has been found to be quite successful. It has been concluded that the presented mathematical method is simple, reliable, and accurate.

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Development of a Sensitive and Selective Method for the Determination of some Selected Aldehydes Based on Fluorescence Quenching

2023

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Micellar catalysis in reactions of some β-lactam antibiotics withp-dimethylaminobenzaldehyde

Cited by 6 publications

References 16 publications

Application of a Schiff base derived from sulfanilamide as an acid-base indicator

Application of a Schiff base derived from sulfanilamide as an acid-base indicator

Statistical and Mathematical Investigations for Determining the Binding Constants of Micelle with Reactants Molecules from Kinetic Data

Development of a Sensitive and Selective Method for the Determination of some Selected Aldehydes Based on Fluorescence Quenching

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