Micellar effects on kinetics and mechanism of Vilsmeier–Haack formylation and acetylation with Pyridines

Amla Fruit Extract: Green and Natural Catalyst for the Synthesis of Acylated Derivatives via Microwave Technique

“…Like our studies, the use of MWs as an alternative energy source for catalytic reactions with shorter synthesis times was reported 24,25 . Acetylation is dramatically accelerated in micellar media cetyltrimethylammonium bromide, sodium dodecyl sulphate, and Triton-X100 under reflux conditions 26,27 . We performed a kinetic investigation of silver nanoparticle production utilizing Phyllanthus emblica amla extract at different concentrations 28 .…”

Unravelling the synthetic and therapeutic aspects of five, six and fused heterocycles using Vilsmeier–Haack reagent

“…Further, the basic hydrolysis of this intermediate (5) results in the formation of the formylated pyridine derivative (6). The resonance stabilization of the iminium ion augments its reactivity, ensuring efficient formylation 68 ( Scheme 32 ).…”

“…In 2022, Tasneem et al 68 showed a significant drain in reaction time in micellar media by using V. H. reagent in formylation and acetylation in pyridine. This reaction follows second order kinetics when {[V. H. reagent] = [Substrate]} and pseudo first order kinetics when {[Substrate] ≫ [V. H. reagent]}.…”

POCl3 mediated one-pot deoxygenative aromatization and electrophilic chlorination of dihydroxy-2-methyl-4-oxo-indeno[1,2-b]pyrroles

“…2 Furthermore, the great attention paid to POCl 3 stems from its diverse applications in chlorination, 3 dehydration, 4 Bischler–Napieralski cyclization, 5 and Vilsmeier–Haack formylation. 6 Dihydroxy-4-oxo-indeno[1,2- b ]pyrroles possessing two vicinal hydroxyl groups have been deoxygenated by reagents such as triphenylphosphine (route A in Scheme 1), 7 thionyl chloride, 8 and tetraalkylthionylamides ((NR 2 ) 2 SO) (route B in Scheme 1). 8,9…”