Micellar HPLC method for the simultaneous determination of three anticonvulsant drugs in dosage forms and biological fluids. Application to dissolution-rate testing

Belal, F.; Ibrahim, F.; Sheribah, Z. A.; Alaa, H.

doi:10.1016/j.pharma.2018.02.003

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…15 Several technologies were adopted for the bio-analysis of LED, SOF or DAC including chromatographic 16,17 and spectroscopic methods. 18,19 However, these procedures for the evaluation of antihepatitis C-drugs are cumbersome in terms of complication and time efficiency. Also, the instrumentation used in the assays is rather expensive.…”

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confidence: 99%

Electrochemical Method for the Determination of Three New Anti-Hepatitis C Drugs: Application in Human Blood Serum

Atta

Ahmed

2018

J. Electrochem. Soc.

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Recently, there is a widespread usage of anti-hepatitis C drugs in the world where the disease is classified as epidemic and life threatening. Direct-acting antivirals drugs, (DAAs), are introduced as promising medication regimens to treat chronic HCV infection. From the clinical point of view, it is necessary to introduce reliable method for the determination of the three new drugs: Daclatasvir (DAC); Sofosbuvir (SOF); and Ledipasvir (LED). For the first time a simple, reliable, time efficient, direct and ultrasensitive sensor is designed for the determination of DAAs. The sensor is constructed by applying a thin layer from a mixture of multi-walled carbon nanotubes-ionic liquid crystal to glassy carbon electrode-surface followed by electrodeposition of cobalt nanoparticles (GC/(CNTs-ILC)/Co). The sensor exhibited excellent electro-catalytic activity toward LED, DAC and SOF determinations in human serum in wide linear dynamic ranges. The detection limits for LED, DAC and SOF were found as: 0.277 nmol L −1 , 1.86 nmol L −1 and 7.29 nmol L −1 respectively. The GC/(CNTs-ILC)/Co sensor has been applied for the simultaneous determination of LED with SOF and in presence of interfering compounds. Furthermore, the application was extended to analysis of combination from LED and SOF in its pharmaceutical formulation.

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confidence: 99%

Electrochemical Method for the Determination of Three New Anti-Hepatitis C Drugs: Application in Human Blood Serum

Atta

Ahmed

2018

J. Electrochem. Soc.

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“…Additionally, VNB was estimated either alone or in combination with other drugs [10][11][12][13][14]. The micellar liquid chromatographic analytical method is one mode of eco-friendly analytical chemistry and is reported for the separation of a number of drugs [15][16][17]. Pharmacokinetic studies on VNB in humans were performed in phase I dose escalation studies [18] and in phase II trials at VNB doses of 100 and 300 mg/day [19].…”

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confidence: 99%

A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation

2022

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Vandetanib (Caprelsa®; VNB) is a prescription medicine that is used for the treatment of medullary thyroid cancer that has disrupted other body parts or that cannot be removed by surgery. It is considered a tyrosine kinase inhibitor (TKI). Fast, sensitive and validated HPLC–UV was established for VNB quantification in pure human biological fluids (urine and plasma) and human liver microsomes (HLMs). This analytical methodology was applied also to the metabolic stability assessment of VNB. This method was performed using a phenyl column (250 mm × 4.6 mm id, 5 µm particle size). A sodium dodecyl sulphate solution (0.05 M, pH 3.0 using 0.02 M orthophosphoric acid) containing 0.3% triethylamine and 10% n-butanol was used as a mobile phase and was pumped isocratically at a flow rate of 0.7 mL/min and at a 260 nm detection wavelength. The total elution time was 6 min with an injection volume of 20 μL. The linearity of the established methodology ranged from 30 to 500 ng/mL in pure form and 50 to 500 ng/mL (r2 ≥ 0.9994) in human biological fluids and HLMs. No significant interference from the matrix components was observed. The proposed methodology revealed the benefits of being green, reliable and economic.

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New and Emerging Antiepileptic Drugs

Witkin

Golani

Smith

2021

Burger's Medicinal Chemistry and Drug Discovery

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This article provides the biologist, chemist, and clinician with an overview into currently existing epilepsy medicines, an appreciation of those currently in development, and a glimpse at future possibilities. The discovery and development of antiepileptic drugs with improved efficacy and side‐effect dimensions are urgently needed. We discuss various strategies for discovering new antiepileptic drugs. We then provide summary data on the mechanisms of action, efficacy, and tolerability of some of the newer third‐generation antiepileptic drugs – eslicarbazepine, brivaracetam, retigabine, lacosamide, and perampanel. Additional compounds that are currently in development for epilepsy are also reviewed. These include the novel α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonists CERC‐611 and JNJ‐55511118 that are first‐in‐class drugs blocking only those AMPA receptors associated with the auxiliary protein TAPP γ‐8. The GABA A (α2/3)‐selective compounds, KRM‐II‐81, MP‐III‐080, and PF‐06372865 hold additional promise and potential advantage over nonselective GABA A receptor modulators. The developmental status of another positive allosteric modulator of GABA A receptors, the neuroactive steroid ganaxolone, is also summarized. In addition, two mGlu2 receptor modulators, JNJ‐40411813 and LY2812223 are discussed. Finally, initial data on cannabidiol, anakinra, and padsevonil are reviewed. Literature data derived from studies on both human epileptic tissue and rodent seizure modeling were utilized to glean several compelling novel drug targets for consideration in future antiepileptic drug discovery programs. Thus, in the past decade, key advances have been made that are benefiting the epileptic patient community. The current compounds in development and new drug targets give additional promise of improved antiepileptic drugs.

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Micellar HPLC method for the simultaneous determination of three anticonvulsant drugs in dosage forms and biological fluids. Application to dissolution-rate testing

Cited by 4 publications

References 23 publications

Electrochemical Method for the Determination of Three New Anti-Hepatitis C Drugs: Application in Human Blood Serum

Electrochemical Method for the Determination of Three New Anti-Hepatitis C Drugs: Application in Human Blood Serum

A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation

New and Emerging Antiepileptic Drugs

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