Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note

Seedher, Neelam; Kanojia, Mamta

doi:10.1208/s12249-008-9057-5

Cited by 103 publications

(58 citation statements)

References 22 publications

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“…According to the study of Bloor et al (2006) examining effect of acidity-alkalinity on quality of Nonionic Surfactant Micellar, the findings revealed that the increase of pH in alkalinity possibly affects size of Nonionic Surfactant Micellar and it is likely to become smaller when being in high alkalinity. In addition, Neelam and Mamta (2008) performed an experiment and discovered that size of Micellar influenced aqueous solubility provided that minute Micellar will be more efficient in solubility than larger ones. Nevertheless, it is because small Micella contains more surfaces than bigger Micellar.…”

Section: Removal Of Chromium With Tween 80mentioning

confidence: 99%

Efficiency of EDTA and TWEEN 80 for the Removal of Chromium using Soil Washing Technologies

Sampanpanish¹,

Thetthotsaporn²

2018

American Journal of Applied Sciences

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Abstract:The study on the efficiency of chelate and surfactant for the removal of chromium using soil washing technology of which the chelate is EDTA and surfactant is TWEEN 80 at concentrations of 8, 16 and 32 millimoles was separately conducted. The experiment soil was synthetic soil with chromium contamination for 2 years. In this study, 20 g of contaminated soil would be washed with 200 milliliters of EDTA and TWEEN 80 with pH values of 2, 4, 6, 8 and 10 before being shaken at speeds of 90, 120 and 150 rpm for 15, 30, 60, 90, 120 and 180 min and at every 3 h until it reached its equilibrium point at room temperature. After that it was filtered with filter paper before digestion with acid whereupon the obtained solution would be further analyzed. The study result revealed that EDTA could remove chromium best at a concentration of 32 millimoles with pH of 10 and shaking speed of 120 rpm and it could eliminate chromium at the level of 38.54%. In the meantime, TWEEN 80 could remove chromium best at a concentration of 32 millimoles with pH of 10 and shaking speed of 150 rpm and it could eliminate chromium at the level of 9.86%. Therefore, when comparing efficiency between EDTA and TWEEN 80, the researcher concluded that EDTA had higher efficiency in removing chromium from soil than TWEEN 80.

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Section: Removal Of Chromium With Tween 80mentioning

confidence: 99%

Efficiency of EDTA and TWEEN 80 for the Removal of Chromium using Soil Washing Technologies

Sampanpanish¹,

Thetthotsaporn²

2018

American Journal of Applied Sciences

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“…Solubilisation is generally used as an alternative method for the dissolution of poorly soluble drugs, depending on the drug hydrophobicity. The solubilisation effect of drugs can occur in the inner core of micelle, on the surface of micelle or at an intermediate location in the palisade layer (Seedher & Kanojia, 2008). For the experiments of VAL solubility, the concentration of SDS in range 0.001-0.07 mol/l at temperature 298.15 K was selected and the concentration of drug was kept constant (0.055 mol/l).…”

Section: Calculation Of Thermodynamic Parametersmentioning

confidence: 99%

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

Stopková

Hriňaková

Bezáková

et al. 2016

European Pharmaceutical Journal

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In this manuscript was investigated behaviour of drug valsartan by micellar media of anionic surfactant sodium dodecyl sulphate. As the method was used electrical conductivity for the determination of critical micelle concentration at different temperatures (T = 293.15 -313.15 K), as well as calculated thermodynamic parameters like standard Gibbs free energy, enthalpy and entropy of micellization. According to contribution of Gibbs free energy is the process of micellization primarily controlled by entropy. Solubilization of valsartan was studied in surfactant system at 298.15 K and physiological conditions pH 7.4 using UVspectrophotometry at different concentration range (0.001 -0.07 mol/l) of sodium dodecyl sulphate. The solubilization of drug was observed with increasing concentration of surfactant in aqueous solution. Valsartan -sodium dodecyl sulphate -critical micelle concentration -micellization -thermodynamics -solubilization

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“…The common cosolvents utilized are glycerin, ethanol, polyethylene glycols (mainly 200, 300 and 400), polyethylene glycol ether, propylene glycol and tetrahydrofurfuryl alcohol [9]- [11]. Surfactants (amphiphilic molecules composed of a hydrophilic moiety known as the head and a hydrophobic moiety known as the tail) have been reported to solubilize a number of poorly water soluble drugs [12]- [16]. They do that by forming colloidal clusters in solutions called micelles.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Solubility Enhancement of Mirtazapine: Effect of Cosolvent and Surfactant

Ezealisiji¹,

Mbah²,

Osadebe³

2015

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The poor aqueous solubility of drugs is a challenging problem faced by pharmaceutical scientists in drug formulation. Cosolvency and micellization techniques have been severally used to enhance the solubility of poorly aqueous soluble drugs. Mirtazapine, a tetracyclic antidepressant used for the treatment of moderate to severe depression and anxiety, has very poor aqueous solubility. The objective of the study was to investigate the effect of solubilizing agents (cosolvents and surfactants) on the aqueous solubility of mirtazapine while envisaging that any significant improvement in its aqueous solubility could contribute towards alleviating the withdrawal symptoms often associated with the drug. The solubility of mirtazapine was determined at room temperature in aqueous mixtures of cosolvents (propylene glycol and polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80 and sodium lauryl sulfate). An exponential increase in mirtazapine solubility was observed when total drug solubility in water-cosolvent system was plotted against cosolvent fraction volume. Polyethylene glycol 400 gave larger solubilization capacity (σ) when compared to propylene glycol. With the surfactants, linear relationship between the total solubility of the drug in water-surfactant mixtures and surfactant concentration was noted. Sodium lauryl sulfate showed the largest solubilization power (k) when compared to the nonionic surfactants (polysorbate 20 and polysorbate 80 respectively). A linear relationship between standard free energy and partition coefficient was also observed. The result of the study shows that aqueous solubility of mirtazapine is significantly improved by cosolvency and micellization and therefore there exists the possibility of improving the withdrawal symptoms often experienced with the drug. It also suggests that large free energy is required for drugs with high partition coefficients to permeate the biological membrane.

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Micellar Solubilization of Some Poorly Soluble Antidiabetic Drugs: A Technical Note

Cited by 103 publications

References 22 publications

Efficiency of EDTA and TWEEN 80 for the Removal of Chromium using Soil Washing Technologies

Efficiency of EDTA and TWEEN 80 for the Removal of Chromium using Soil Washing Technologies

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

Aqueous Solubility Enhancement of Mirtazapine: Effect of Cosolvent and Surfactant

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