Micelle-Assisted C(sp²)–H Functionalization for C–Se and C–X Bond Formation in the Aqueous Medium

Abstract

An environmentally sustainable, versatile, and costeffective approach for C−Se and C−X (X = I, Br, and Cl) bond formation through C−H functionalization assisted by micellar catalysis in water is developed. The reaction utilizes a minimum amount of diorganyl diselenides and potassium halides for the respective functionalizations. The present protocol was suitable for scale-up synthesis, which directly provided the desired selenylated products without the need for chromatographic purification, in sufficient purity. The aqueous micellar catalysis system was reusable for up to 5 reaction cycles without compromising the reaction yield.