Micelle Formation and Phase Separation of Poloxamer 188 and Preservative Molecules in Aqueous Solutions Studied by Small Angle X-ray Scattering

Thermosensitive biomaterial gels with chemical permeation enhancers for enhanced microneedle delivery of naltrexone for managing opioid and alcohol dependency

“…On increasing DMSO content from 5% to 10%, the gelation temperature decreased by ∼3–4 °C to 18.0 ± 0.5 °C and 21.8 ± 0.2 °C with and without 1% benzyl alcohol, respectively. Overall, the presence of benzyl alcohol and/or DMSO lowered gelation temperature compared to formulations without CPE (DMSO has been previously shown to decrease gelation temperature of P407 formulations 31,32 ). The overall trend of decreasing gelation temperature observed upon addition of CPEs could be attributed to water molecules having more affinity for CPEs; this would result in fewer free water molecules to interact with poloxamer, increasing the need to generate micelles.…”

3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP)

“…NCRs again generated a protective effect up to certain concentrations of niclosamide, which we believe may be due to the presence of P188. The ability of P188 to form aggregates in which free niclosamide can be trapped is documented [ 39 ]. This phenomenon would decrease the amount of free niclosamide available in the medium, thus decreasing toxicity to some extent.…”