Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: comparison with other unconjugated bile salts

Ninomiya, Ryoko; Matsuoka, K.; Moroi, Yoshikiyo

doi:10.1016/j.bbalip.2003.09.003

Cited by 90 publications

(97 citation statements)

References 28 publications

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“…DXR release was observed below the critical micelle concentration (cmc: approx. 3 mM 24) ), and the percentage of released DXR reached almost 100% at 3.3 mM (Fig. 1a).…”

Section: Resultsmentioning

confidence: 99%

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Alterations in the Detergent-Induced Membrane Permeability and Solubilization of Saturated Phosphatidylcholine/Cholesterol Liposomes: Effects of Poly(ethylene glycol)-Conjugated Lipid

Shibata¹,

Saito²,

Yomota³

et al. 2012

Chem. Pharm. Bull.

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We have investigated the effects of two bile salts, chenodeoxycholate (CDC) and ursodeoxycholate (UDC), and a widely used detergent, Triton X-100 (T X-100 ), on normal and poly(ethylene glycol)-modified liposomes (PEGylated liposomes). We tested various lipid compositions, including hydrogenated soybean phosphatidylcholine/cholesterol/PEG-conjugated lipid (HSPC/PEG-lipid). Alterations in permeability were determined by the rate of drug release from the liposomes and solubilization was assessed by measuring the particle size of liposomes. In addition, we attempted to observe interactions between the detergents and lipid bilayers by using surface plasmon resonance (SPR). CDC induced drug release from liposomes in a dose-dependent manner, and the PEGylated liposomes tended to be susceptible to CDC. While UDC did not strongly induce drug release from liposomes, UDC exhibited a similar tendency with CDC. In case of T X-100 , there were significant differences in the percentage of released drug between normal and PEGylated liposomes, and the percentage of T X-100 -induced drug release further increased with an increased ratio of PEG-lipid. SPR analysis revealed that the lipid bilayer including PEG-lipid was selectively solubilized by T X-100 , correlating with the drug release data. These results suggest that the effect of detergents on the lipid bilayer of liposomes depends on both the kind of detergent and the lipid composition, including the presence or absence of PEG-lipid. Moreover, the effects of T X-100 on the lipid bilayers of the PEGylated liposomes significantly differed from those on the lipid bilayers of the normal liposomes.

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“…DXR release was observed below the critical micelle concentration (cmc: approx. 3 mM 24) ), and the percentage of released DXR reached almost 100% at 3.3 mM (Fig. 1a).…”

Section: Resultsmentioning

confidence: 99%

“…12 mM 24) ), the rate of release of DXR from the PEGylated liposomes (SL1 and SL2) tended to be slightly higher than that from normal liposomes (Fig. 1b).…”

Section: Resultsmentioning

confidence: 99%

Alterations in the Detergent-Induced Membrane Permeability and Solubilization of Saturated Phosphatidylcholine/Cholesterol Liposomes: Effects of Poly(ethylene glycol)-Conjugated Lipid

Shibata¹,

Saito²,

Yomota³

et al. 2012

Chem. Pharm. Bull.

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“…The spectral characteristics of the Pc monomer (l max = 686 nm, lge = 5.15) presented in a PSS/ SDS solution are close to those for Mgcr 8 Pc in CH 2 Cl 2 or an aqueous micellar solution of SDS. [6] In contrast, the addition of sodium deoxycholate ([SDC] = 4.76•10 -3 M is close to its cmc 1 ) [17] to the Mgcr 8 Pc/ PSS solution leads only to a slight increase of the absorbance. Anionic surfactant SDC is specified by 'planar' diphilicity manifested in the formation of convex (hydrophobic) and concave (hydrophilic) surfaces.…”

Section: Magnesium Octa[(4'-benzo-15-crown-5)oxy] Phthalocyaninate Inmentioning

confidence: 99%

Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

Gol’dshleger¹,

Gak²,

Lobach³

et al. 2015

MHC

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“…For many years, the measurement and the existence itself of the critical micelle concentration (CMC) in aqueous solutions of bile salts (BS) has been a debated question [1][2][3][4][5][6]. It has been shown that the CMC values determined by the same technique in different laboratories are very dispersed, especially for the trihydroxy bile salts [2,[6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that the CMC values determined by the same technique in different laboratories are very dispersed, especially for the trihydroxy bile salts [2,[6][7][8][9]. Furthermore, it has been demonstrated that the CMC measurements made in one laboratory using different techniques are also not in good agreement [2,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The CMC-like behaviour of bile salts as probed by photoexcited Rose Bengal

Seret

Bahri

2009

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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The onset of the aggregation process in aqueous bile salt (BS) solutions remains a debated question. This study aimed at investigating this point through the detection of BS monomers and small aggregates using the dye Rose Bengal. Results showed that a few small BS aggregates led to a red shift of the absorption spectrum, while the BS monomer reacted with the photo-induced semi-oxidized dye and decreased its decay rate constant. The dye was dissolved in aqueous solution (10 mmol dm -3 NaOH) of sodium cholate (NaC), deoxycholate (NaDC), chenodoxycholate (NaCDC), dehydrocholate (NaDHC), glycocholate (NaGC) glycodeoxycholate (NaGDC), taurocholate (NaTC), taurodeoxycholate (NaTDC) and the zwitterionic analogue of sodium cholate called CHAPS. BS aggregates were detected at concentrations well below the concentration above which any added bile salt molecules

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Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: comparison with other unconjugated bile salts

Cited by 90 publications

References 28 publications

Alterations in the Detergent-Induced Membrane Permeability and Solubilization of Saturated Phosphatidylcholine/Cholesterol Liposomes: Effects of Poly(ethylene glycol)-Conjugated Lipid

Alterations in the Detergent-Induced Membrane Permeability and Solubilization of Saturated Phosphatidylcholine/Cholesterol Liposomes: Effects of Poly(ethylene glycol)-Conjugated Lipid

Supramolecular Organization of Magnesium Octa[(4’-benzo- 15-crown-5)oxy]phthalocyaninate in Aqueous Solutions of Polyelectrolytes and Surfactants: Analysis by Spectral Methods

The CMC-like behaviour of bile salts as probed by photoexcited Rose Bengal

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