Micelle formation of Tyr-Phe dipeptide and Val-Tyr-Val tripeptide in aqueous solution and their influence on the aggregation of SDS and PEO–PPO–PEO copolymer micelles

The aggregation of Tyr-Phe dipeptide and Val-Tyr-Val tripeptide in aqueous solution and in the presence of SDS and PEO–PPO–PEO triblock copolymer: Fluorescence spectroscopic studies

“…However, in the present case, the constant surface tension had been obtained at higher concentration indicates that the mixed micelles formed with homogeneous characteristics [18]. The investigated PEO-PPO-PEO co polymer is insoluble in water.…”

“…The presence of additives (SDS and polymer) hindered the micelle formation of peptides. The cmc of SDS was decreased in presence of peptides and polymer, which suggest that the micelle formation of SDS is facilitated in the presence of these additives (peptides and polymer) [18,36]. In system-I [polymer (varying) + 25 mM SDS (fixed] and II [SDS (varying) + 5 mM polymer (fixed)], the effects of SDS and polymer micelles on the micelle formation of polymer and SDS, respectively, had been demonstrated [36,37] recently by cyclic voltammetric (CV) and dynamic light scattering (DLS) techniques.…”

“…On an average, the hydrodynamic radius (R m h ) values of systems-I, II and SDS alone (obtained by different methods) are 30, 63, and 20 Å, respectively [37]. In the same analogy, the peptides get adsorb on the surface of SDS micelles [7,18,36]. However, sizes of the peptide-SDS-polymer mixed micelles are not yet known.…”

“…Micellization and aggregation do not normally occur at one very well-defined concentration, but over a limited range. The cmc of small peptide provides a good example of this, where small but significant differences had been detected by different methods [18]. We have found in the recent past [19], where clear breaks were observed at a small concentration of hydantoin drug (say, 0.01 mM) in aqueous solution upon plotting various physicochemical properties of hydantoin as a function of its concentration using different techniques.…”

“…Recently [18], the micelle formation of Tyr-Phe dipeptide and Val-Tyr-Val tripeptide were studied in aqueous solution and in the presence of SDS and PEO-PPO-PEO triblock copolymer. Micellization and aggregation do not normally occur at one very well-defined concentration, but over a limited range.…”