Micelles driven magnetite (Fe3O4) hollow spheres and a study on AC magnetic properties for hyperthermia application

Goswami, Madhuri Mandal; Dey, Chaitali; Bandyopadhyay, A. K.; Sarkar, Debasish; Ahir, Manisha

doi:10.1016/j.jmmm.2016.05.069

Cited by 35 publications

(13 citation statements)

References 20 publications

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“…Urea helps to precipitate Fe +3 and Fe +2 to their corresponding hydroxides where the hydroxyl group comes from ammonium-hydroxide produced from urea and after the heat treatment both the iron hydroxides forms Fe 3 O 4 through removal of water. The possible chemical reaction is given below what is shown in our previous published result27.…”

Section: Methodsmentioning

confidence: 76%

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Goswami

2016

Sci Rep

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This paper reports on synthesis of hollow spheres of magnetite, guided by micelles and their application in drug release by the stimulus responsive technique. Here oleyelamine micelles are used as the core substance for the formation of magnetite nano hollow spheres (NHS). Diameter and shell thickness of NHS have been changed by changing concentration of the micelles. Mechanism of NHS formation has been established by investigating the aliquot collected at different time during the synthesis of NHS. It has been observed that oleyelamine as micelles play an important role to generate hollow-sphere particles of different diameter and thickness just by varying its amount. Structural analysis was done by XRD measurement and morphological measurements, SEM and TEM were performed to confirm the shape and size of the NHS. FTIR measurement support the formation of magnetite phase too. Frequency dependent AC magnetic measurements and AC magnetic field stimulated drug release event by these particles provide a direction of the promising application of these NHS for better cancer treatment in near future. Being hollow & porous in structure and magnetic in nature, such materials will also be useful in other applications such as in removal of toxic materials, magnetic separation etc.

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Section: Methodsmentioning

confidence: 76%

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Goswami

2016

Sci Rep

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“…Ferromagnetic and superparamagnetic nanoparticles can be used in hyperthermia as they can generate local heating under external alternating current (ac) magnetic field. Local heating under ac magnetic field takes place due to hysteresis loss, and eddy current ,. Use of anticancer drug is harmful for both of cancer and normal cells.…”

Section: Introductionmentioning

confidence: 99%

“…Nanomaterials are showing well prospect in this case. However, for targeted delivery some external stimuli like pH, [14] temperature, [15] magnetic field [16] etc. [17] can help in better way for drug release.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

et al. 2018

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This work reports the application possibilities of cobalt ferrite (CoFe O ) magnetic nanoparticles (CFMNPs) for stimuli responsive drug delivery by magnetic field induced hyperthermia technique. The CFMNPs were characterized by X-ray diffraction (XRD) with Rietveld analysis, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED), fourier transform infrared spectroscopy (FTIR), thermogravimetry and differential thermal analysis (TG-DTA), vibrating sample magnetometer (VSM) and superconducting quantum interference device (SQUID) magnetometry. Particles were functionalized with folic acid (FA) by EDC-NHS coupling method and loaded with anticancer drug (DOX) by activated folate ions. The drug release was studied as a function of time at two different temperatures (37 and 44 °C) under pH∼5.5 and 7. It was observed that the drug release rate is higher at elevated temperature (44 °C) and acidic pH∼5.5 as compared to our normal body temperature and pH∼7 using the CFMNPs. This way, we have developed a pH and temperature sensitive drug delivery system, which can release the anticancer drug selectively by applying ac magnetic field as under ac field particles are heated up. We have calculated the amount of heat generation by the particles around 1.67 °C per second at ∼600 Hz frequency. By MTT assay on cancer cell and normal cell, it was confirmed that CFMNPs are nontoxic and biocompatible in nature, which assures that our synthesized particles can be successfully used in localized cancer treatment by stimuli responsive drug delivery technique.

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“…Transition‐metal‐based magnetic nano‐scale particles have drawn the attention of researchers because of their particular properties such as their high surface area, low toxicity, excellent chemical stability, and biodegradability. As a result of their magnetic properties and biodegradability, they are used in drug delivery, magnetic resonance cell imaging, magnetic hyperthermia, dye adsorption, magnetic separation, wastewater treatment, and heavy‐metal removal . Such magnetic nanoparticles are also applicable as catalysts in industry .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Cube‐Shaped NiFe₂O₄ Nanoparticles: An Effective Model Catalyst for Nitro Compound Reduction

Dey

Chaudhuri

Ghosh³

et al. 2017

ChemCatChem

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Noble‐metal nanocatalysts are quite popular, but the use of magnetic catalysts composed of ferrite materials is rare. Here, we have synthesized transition‐metal‐based cube‐shaped nanoparticles of approximately 11 nm in size, the so‐called magnetic nickel ferrite nanocatalyst (NFNC), by a new method and shown its use in the reduction of nitroaromatic compounds. The NFNC was characterized by using XRD, energy‐dispersive X‐ray spectroscopy, TEM, and field‐emission SEM to confirm the structural features and morphology of the particles. The catalytic activity of NFNC was investigated in the reduction of 4‐nitrophenol to 4‐aminophenol by monitoring the reaction by using UV/Vis spectroscopy. The catalytic activity, recyclability and reusability, rate constant of the reaction, and surface area were investigated in detail to understand the catalytic phenomenon. We measured up to 30 cycles of the catalytic reaction using our NFNC, which shows the high stability of the catalyst. BET analysis of the NFNC shows a surface area of 54.60 m2 g−1. Our NFNC has many advantages because it is prepared easily, cost effective, highly stable, and environmentally compatible. The magnetic properties of the NFNC help us to separate the particles easily after its use in the reduction without disturbing the final product.

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Micelles driven magnetite (Fe3O4) hollow spheres and a study on AC magnetic properties for hyperthermia application

Cited by 35 publications

References 20 publications

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

Magnetic Cube‐Shaped NiFe₂O₄ Nanoparticles: An Effective Model Catalyst for Nitro Compound Reduction

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Micelles driven magnetite (Fe3O4) hollow spheres and a study on AC magnetic properties for hyperthermia application

Cited by 35 publications

References 20 publications

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

Magnetic Cube‐Shaped NiFe2O4 Nanoparticles: An Effective Model Catalyst for Nitro Compound Reduction

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Magnetic Cube‐Shaped NiFe₂O₄ Nanoparticles: An Effective Model Catalyst for Nitro Compound Reduction